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Fasting plasma glucose cutoff value for the prediction of future diabetes development: a study of middle-aged Koreans in a health promotion center.

Authors
Kim, DJ; Cho, NH; Noh, JH; Kim, HJ; Choi, YH; Jung, JH; Min, YK; Lee, MS; Lee, MK; Kim, KW
Citation
Journal of Korean medical science, 20(4):562-565, 2005
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
We determined optimal fasting plasma glucose (FPG) cutoff values predictive of future diabetes development in a group of middle-aged Koreans who visited a health promotion center. The medical records of 2,964 subjects, who attended the Health Promotion Center in 1998 and 2003, were examined. Subjects were classified into four groups according to their baseline FPG values (Group 1:FPG <5.0 mM/L; Group 2: 5.0< or =FPG <5.6 mM/L; Group 3: 5.6< or =FPG <6.1 mM/L; Group 4: 6.1< or =FPG <7.0 mM/L). No significant difference was observed between Group 1 and Group 2 in terms of diabetes incidence. However, incidence in Group 3 was significantly higher than that in Group 1 [hazards ratio 4.88 (1.65-14.41), p=0.004] and the hazards ratio in Group 4 for diabetes was 36.91 (13.11-103.61), p<0.001, versus Group 1. Receiver operator characteristics curve analysis showed that an FPG of 5.97 mM/L represents the lower limit and gives the best combination of sensitivity and specificity. Our data shows that the risk of future diabetes development started to increase below an FPG of 6.1 mM/L and suggests the importance of efforts to modify diabetes development risk factors at lower impaired fasting glucose levels.
MeSH terms
AdultAgedBlood Glucose/metabolism*Blood PressureBody Mass IndexCholesterol, HDL/bloodCholesterol, LDL/bloodCommunity Health Centers/statistics & numerical dataDiabetes Mellitus/blood*Diabetes Mellitus/epidemiologyDiabetes Mellitus/etiologyFasting/blood*FemaleFollow-Up StudiesHealth Promotion*HumansIncidenceKorea/epidemiologyMaleMiddle AgedPredictive Value of TestsRisk FactorsTriglycerides/blood
DOI
10.3346/jkms.2005.20.4.562
PMID
16100444
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
AJOU Authors
조, 남한
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