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Lack of association between hepatitis B virus infection and polymorphism of mannose-binding lectin gene in Korean population.

Authors
Cheong, JY; Cho, SW; Lim, SK; Shin, DH; Yoon, SK; Lee, JE; Hahm, KB; Kim, JH
Citation
Journal of Korean medical science, 20(1):65-69, 2005
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Mannose-binding lectin (MBL) plays an important role in immune defense. This study was undertaken to investigate the association between hepatitis B virus infection and polymorphisms of MBL gene. We assessed the single nucleotide polymorphism at codon 54 in exon 1 of MBL in patients with hepatitis B virus infection and HBsAg negative controls in Korean population. A total of 498 enrolled subjects was classified into four groups. Group 1; Clearance, Group 2; Inactive healthy carrier, Group 3; Chronic hepatitis, Group 4; Liver cirrhosis. MBL gene polymorphisms at codon 54 led to three genotypes (G/G, G/A, A/A). When we divided subjects into clearance group (group 1) and persistence group (group 2-4), G/G genotype and A-allele carrier were observed in 55.6% and 44.4% in clearance group, 64.8% and 35.2% in persistence group (p=0.081), respectively. When hepatitis B virus persistent cases were divided into inactive healthy carrier (group 2) and disease progression group (group 3 and 4), MBL gene polymorphisms at codon 54 were not related to disease progression (p=0.166). MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection.
MeSH terms
AdultAllelesCodonDisease ProgressionFemaleFibrosisGenotypeHepatitisHepatitis B/genetics*Hepatitis B/metabolism*Hepatitis B virus/metabolism*HeterozygoteHumansKoreaLectins*MaleMannose-Binding Lectin/chemistry*Mannose-Binding Lectin/genetics*Middle AgedPolymorphism, Genetic*Polymorphism, Single Nucleotide
DOI
10.3346/jkms.2005.20.1.65
PMID
15716605
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연조, 성원함, 기백김, 진홍
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