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Efficacy of myocardial contrast echocardiography in the diagnosis and risk stratification of acute coronary syndrome.

Kang, DH; Kang, SJ; Song, JM; Choi, KJ; Hong, MK; Song, JK; Park, SW; Park, SJ
The American journal of cardiology, 96(11):1498-1502, 2005
Journal Title
The American journal of cardiology
We examined the hypothesis that myocardial contrast echocardiography (MCE) is superior to conventional electrocardiographic, echocardiographic, and troponin I criteria for the diagnosis of acute coronary syndrome. We prospectively enrolled 114 consecutive patients (60+/-10 years of age, 73 men) who presented to the emergency room with chest pain on exertion and at rest. Exclusion criteria included an age<40 years, presence of Q wave or ST-segment elevation, and a poor echocardiographic window. Echocardiography and MCE were performed to assess regional wall motion abnormalities (RWMAs) and myocardial perfusion defects by using continuous infusion of perfluorocarbon-exposed sonicated dextrose albumin. Acute coronary syndrome was confirmed in 87 patients. There were no deaths; 46 patients had acute myocardial infarction, and 41 patients required urgent revascularization. On multiple logistic regression analysis, myocardial perfusion defect (odd ratio 87, p<0.001) was the only independent variable for diagnosing acute coronary syndrome. Myocardial perfusion defect (odd ratio 21, p=0.001) and troponin I levels (odd ratio 3, p=0.009) were independent predictors for acute myocardial infarction. The sensitivity of myocardial perfusion defect for diagnosing acute coronary syndrome was 77%, which is significantly higher than the sensitivities of ST change, troponin I increase, and RWMA (28%, 34%, and 49%, respectively), with similar specificities of 85% to 96%. In conclusion, MCE is more sensitive than the currently used electrocardiographic and troponin I criteria, and evaluation of myocardial perfusion defect by MCE complements RWMA analysis by conventional echocardiography for accurate diagnosis of acute coronary syndrome.
MeSH terms
Acute DiseaseCoronary Disease/bloodCoronary Disease/physiopathologyCoronary Disease/ultrasonography*Diagnosis, DifferentialEchocardiography, Doppler/methods*ElectrocardiographyFemaleFluorocarbons/administration & dosageFluorocarbons/diagnostic use*Follow-Up StudiesGlucose/administration & dosageGlucose/diagnostic use*HumansInfusions, IntravenousMaleMiddle AgedMyocardial Contraction/physiologyOdds RatioProspective StudiesReproducibility of ResultsRisk Assessment/methods*Sensitivity and SpecificitySerum Albumin/administration & dosageSerum Albumin/diagnostic use*Severity of Illness IndexSyndromeTroponin I/blood
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