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Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness.

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dc.contributor.authorKim, SH-
dc.contributor.authorBae, JS-
dc.contributor.authorSuh, CH-
dc.contributor.authorNahm, DH-
dc.contributor.authorHolloway, JW-
dc.contributor.authorPark, HS-
dc.date.accessioned2011-06-23T05:55:54Z-
dc.date.available2011-06-23T05:55:54Z-
dc.date.issued2005-
dc.identifier.issn0105-4538-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3015-
dc.description.abstractBACKGROUND: 5-Lipooxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) are known as key enzymes in cysteinyl-leukotriene (cys-LT) production, critical mediators in aspirin acetylsalicyclic acid (ASA)-intolerant asthma (AIA). To date, studies of the promoter region of ALOX5 gene has revealed the potential influence of a variable number of tandem repeats of a Sp1- and Egr1-binding motif, on the transcription rate.



METHODS: To understand the pathological process that arises from cys-LT overproduction in AIA, we genotyped ALOX5 Sp1 and ALOX5AP poly(A) repeat promoter polymorphism by fluorescent-based capillary electrophoresis in the Korean population.



RESULTS: No significant differences in allele and genotype frequencies of the ALOX5 and ALOX5AP promoter polymorphisms were observed between the three groups. However, there was a strong association of the ALOX5 Sp1 repeat polymorphism with airway hyperresponsiveness (AHR; PC20 methacholine); AIA patients carrying a mutant allele (n > 5 or n < 5 repeats) showed increased AHR compared to AIA patients with wild-type genotype (P=0.003).



CONCLUSION: Although the alleles of the ALOX5 and ALOX5AP promoter cannot be considered as a prominent risk factor in the development of AIA, the genetic variant of tandem repeat (GGGCGG; Sp1-binding motif) in ALOX5 promoter is associated with the severity of airway hyperresponsiveness in AIA patients.
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dc.language.isoen-
dc.subject.MESH5-Lipoxygenase-Activating Proteins-
dc.subject.MESHArachidonate 5-Lipoxygenase-
dc.subject.MESHAspirin-
dc.subject.MESHAsthma-
dc.subject.MESHCarrier Proteins-
dc.subject.MESHDrug Hypersensitivity-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMembrane Proteins-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHTandem Repeat Sequences-
dc.titlePolymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness.-
dc.typeArticle-
dc.identifier.pmid15876305-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=2005&volume=60&issue=6&spage=760-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor남, 동호-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1398-9995.2005.00780.x-
dc.citation.titleAllergy-
dc.citation.volume60-
dc.citation.number6-
dc.citation.date2005-
dc.citation.startPage760-
dc.citation.endPage765-
dc.identifier.bibliographicCitationAllergy, 60(6). : 760-765, 2005-
dc.identifier.eissn1398-9995-
dc.relation.journalidJ001054538-
Appears in Collections:
Journal Papers > Hospital > Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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