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Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema.

Authors
Choi, JH; Kim, SH; Suh, CH; Nahm, DH; Park, HS
Citation
Journal of Korean medical science, 20(3):367-372, 2005
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
The pathogenic mechanism of ASA-induced urticaria/angioedema (AIU) is still poorly understood, but it has been known that histamine releasing by cutaneous mast cell activation is considered to be an important role. Considering the importance of histamine in AIU, we speculated that a genetic abnormality of histamine-related genes such as a high-affinity IgE receptor, a metabolic enzyme of histamines and histamine receptors, may be involved in the development of AIU. Enrolled in the study were 110 patients with AIU, 53 patients without ASA hypersensitivity who had various drug allergies presenting as exanthematous skin symptoms, and 99 normal healthy controls (NC). Eleven single nucleotide polymorphisms (SNPs) of the beta chain of the high-affinity IgE receptor (FCER1B) and three histamine-related genes-histamine N-methyltransferase (HNMT), histamine H1 receptor (HRH1), histamine H2 receptor (HRH2)-were screened using the SNP-IT assay based on a single base extension method. No significant differences were observed in allele and genotype frequencies, and haplotype frequencies of all the SNPs of FCER1B, HNMT, HRH1, and HRH2 among the three groups (p>0.05, respectively). These results suggest that the polymorphisms of FCER1B and the three histamine-related genes may not contribute to the development of AIU phenotype in the Korean population.
MeSH terms
AdultAllelesAngioedema/chemically inducedAngioedema/genetics*Angioedema/metabolismAspirinFemaleGene FrequencyGenotypeHaplotypesHistamine/metabolism*Histamine Release/geneticsHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single Nucleotide*Receptors, IgE/genetics*Urticaria/chemically inducedUrticaria/genetics*Urticaria/metabolism
DOI
10.3346/jkms.2005.20.3.367
PMID
15953854
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
김, 승현서, 창희남, 동호박, 해심
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