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Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.

Authors
Kim, SH; Choi, JH; Holloway, JW; Suh, CH; Nahm, DH; Ha, EH; Park, CS; Park, HS
Citation
Journal of Korean medical science, 20(6):926-931, 2005
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
The pathogenesis of aspirin (acetylsalicylic acid, ASA)-intolerant urticaria (AIU) is still poorly understood but it has recently been suggested that it is associated with the overproduction of leukotriene (LT). This is supported by evidence that cyclooxygenase 2 inhibitor is given safely to patients with AIU. The present study was designed to investigate the role of genetic polymorphism of LT related genes in the pathogenesis of AIU via a case-control study. We screened single nucleotide polymorphisms (SNPs) in genes encoding enzymes involved in leukotriene synthesis in the Korean population with AIU (n = 101), ASA-intolerant asthma (AIA, n = 95) and normal healthy controls (n = 123). Genotype was determined by primer extension reactions using the SNapShot ddNTP primer extension kit. Among 8 SNPs of four LT related genes, the polymorphism of ALOX5 at positions of -1708 G > A showed significant difference in genotype frequency between AIU and AIA (p = 0.01). Furthermore, there were significant differences observed in the frequencies of two ALOX5 haplotypes between the AIU group and AIA group (p < 0.05). However, there were no differences in allele, genotype, or haplotype frequencies of ALOX5 between the AIU group and the normal control group. These results suggested that ALOX5 has a differing contribution in two major clinical pathogenesis related to ASA-sensitivity.
MeSH terms
5-Lipoxygenase-Activating ProteinsAdultArachidonate 5-Lipoxygenase/genetics*Aspirin/adverse effects*Asthma/etiologyAsthma/genetics*Asthma/metabolismCarrier Proteins/geneticsCase-Control StudiesCyclooxygenase 2/geneticsFemaleGene FrequencyGenotypeGlutathione Transferase/geneticsHumansLeukotrienes/biosynthesis*MaleMembrane Proteins/geneticsMiddle AgedPolymorphism, Single NucleotideUrticaria/etiologyUrticaria/genetics*Urticaria/metabolism
DOI
10.3346/jkms.2005.20.6.926
PMID
16361798
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
김, 승현서, 창희남, 동호박, 해심
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