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Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin.

Authors
Choi, S; Park, HS; Cheon, MS; Lee, K
Citation
Archivum immunologiae et therapiae experimentalis, 53(2):151-158, 2005
Journal Title
Archivum immunologiae et therapiae experimentalis
ISSN
0004-069X1661-4917
Abstract
INTRODUCTION: Aspirin is a popular nonsteroidal anti-inflammatory drug, but some patients suffer from hypersensitivity to it. This prompted us to identify the factors or molecules related to these responses.



MATERIAL/METHODS: A commercially available DNA microarray was used to study changes in gene expression in human peripheral blood mononuclear cells (PBMCs) after aspirin treatment. The PBMCs were collected from a patient with aspirin-intolerant asthma and one normal healthy control.



RESULTS: We identified 61 and 107 genes respectively induced and repressed by aspirin treatment in the PBMCs derived from the normal control. In the patient showing aspirin-induced asthma responses, 31 genes were up-regulated and 6 were down-regulated after aspirin treatment. Among these,1 gene was expressed with the same pattern in the control and the patient. In contrast, 19 genes showed different expression patterns, and it turned out that most of them were involved in immune responses, cell growth/proliferation, transcription/translation, and signaling pathways.



CONCLUSIONS: These results show the molecules involved in hypersensitivity to aspirin and may lead to a better understanding of adverse responses to aspirin. Furthermore, they can provide clues for identifying novel therapeutic and/or preventive molecular targets of the adverse effects of aspirin.
MeSH terms
AdultAnti-Inflammatory Agents, Non-Steroidal/adverse effects*Aspirin/adverse effects*Asthma/chemically inducedAsthma/geneticsCase-Control StudiesDNA, Complementary/geneticsDrug Hypersensitivity/geneticsGene Expression/drug effects*Gene Expression ProfilingHumansLeukocytes, Mononuclear/drug effects*Leukocytes, Mononuclear/metabolism*MaleOligonucleotide Array Sequence Analysis
PMID
15928584
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
박, 해심
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