68 336

Cited 797 times in

Autologous mesenchymal stem cell transplantation in stroke patients.

Authors
Bang, OY; Lee, JS; Lee, PH; Lee, G
Citation
Annals of neurology, 57(6):874-882, 2005
Journal Title
Annals of neurology
ISSN
0364-51341531-8249
Abstract
Mesenchymal stem cell (MSC) transplantation improves recovery from ischemic stroke in animals. We examined the feasibility, efficacy, and safety of cell therapy using culture-expanded autologous MSCs in patients with ischemic stroke. We prospectively and randomly allocated 30 patients with cerebral infarcts within the middle cerebral arterial territory and with severe neurological deficits into one of two treatment groups: the MSC group (n = 5) received intravenous infusion of 1 x 10(8) autologous MSCs, whereas the control group (n = 25) did not receive MSCs. Changes in neurological deficits and improvements in function were compared between the groups for 1 year after symptom onset. Neuroimaging was performed serially in five patients from each group. Outcomes improved in MSC-treated patients compared with the control patients: the Barthel index (p = 0.011, 0.017, and 0.115 at 3, 6, and 12 months, respectively) and modified Rankin score (p = 0.076, 0.171, and 0.286 at 3, 6, and 12 months, respectively) of the MSC group improved consistently during the follow-up period. Serial evaluations showed no adverse cell-related, serological, or imaging-defined effects. In patients with severe cerebral infarcts, the intravenous infusion of autologous MSCs appears to be a feasible and safe therapy that may improve functional recovery.
MeSH terms
AdultAgedCells, CulturedFemaleFollow-Up StudiesHumansInfarction, Middle Cerebral Artery/pathologyInfarction, Middle Cerebral Artery/therapy*Injections, IntravenousMagnetic Resonance ImagingMaleMesoderm/cytologyMiddle AgedPrognosisRecovery of FunctionStem Cell Transplantation*/adverse effectsTransplantation, AutologousTreatment Outcome
DOI
10.1002/ana.20501
PMID
15929052
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
방, 오영이, 필휴이, 광
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse