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Presence of human mycoplasma DNA in gastric tissue samples from Korean chronic gastritis patients.

Authors
Kwon, HJ; Kang, JO; Cho, SH; Kang, HB; Kang, KA; Kim, JK; Kang, YS; Song, BC; Kang, HW; Shim, MJ; Kim, HS; Kim, YB; Hahm, KB; Kim, BJ; Kook, MC; Chung, MH; Hyun, JW
Citation
Cancer science, 95(4):311-315, 2004
Journal Title
Cancer science
ISSN
1347-90321349-7006
Abstract
We aimed to determine whether mycoplasmas are present in Korean chronic gastritis, and to understand their roles in gastric cancer tumorigenesis, because mycoplasmas resemble Helicobacter pylori in terms of ammonia production and induction of inflammatory cytokines in immune and non-immune cells. The presence and identity of mycoplasmas were assessed by semi-nested PCR and sequencing, and the results were compared with pathologic data. Fifty-six samples collected from Korean chronic gastritis patients were used for this study. Twenty-three (41.1%) were positive for mycoplasmas. Eighteen sequenced samples contained a single human mycoplasma or two mycoplasmas, which were identified as Mycoplasma faucium (13/18), M. fermentans (3/18), M. orale (1/18), M. salivarium (2/18), and M. spermatophilum (1/18). Mycoplasma-infected chronic gastritis samples showed significantly more severe neutrophil infiltration than non-infected samples (P = 0.0135). Mycoplasma profiles in the oral cavity (M. salivarium is major) and stomach were different, and the presence of significant proinflammatory responses in mycoplasma-positive patients suggests that the mycoplasmas are not simply contaminants. Further studies are required to understand whether mycoplasmas play a role in gastric tumorigenesis.
MeSH terms
Chronic DiseaseDNA, Bacterial/*isolation & purificationGastritis/metabolism/*microbiologyGastroscopyHumansKorea/epidemiologyMolecular Sequence DataMouth/microbiologyMycoplasma/genetics/*isolation & purification/pathogenicityMycoplasma Infections/epidemiology/genetics/*microbiologyMycoplasma fermentans/genetics/isolation & purification/pathogenicityMycoplasma salivarium/genetics/isolation & purification/pathogenicityOrgan SpecificityPyloric Antrum/microbiologySequence Analysis, DNAStomach/microbiologyStomach Neoplasms/*etiology
PMID
15072588
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
김, 영배함, 기백
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