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Two cases of acute myeloid leukemia with t(16;21)(p11;q22) and TLS/FUS-ERG fusion transcripts.

Authors
Chang, WR; Park, IJ; Lee, HW; Park, JS; Kim, HC; Kim, HJ; Han, JH; Cho, SR
Citation
The Korean journal of laboratory medicine, 29(5):390-395, 2009
Journal Title
The Korean journal of laboratory medicine
ISSN
1598-6535
Abstract
Many AML-associated chromosomal abnormalities, such as t(8;21), t(15;17), inv(16), t(9;11), t(9;22) and t(6;9) are well known. The chromosomal aberration of t(16;21)(p11;q22) in AML is rare and it is known to be associated with poor prognosis, young age (median age, 22 yr), and involvement of various subtypes of the French-American-British classification. We report here 2 AML patients with t(16;21)(p11;q22), proved by conventional cytogenetics and/or reverse transcription (RT)-PCR. Erythrophagocytosis by leukemic blasts was observed in both of the cases. One patient was a 24 yr-old male with acute myelomonocytic leukemia. His karyotype was 46,XY,t(16;21)(p11;q22),del(18)(p11.2) and RT-PCR revealed the TLS/FUS-ERG fusion transcripts. Although he received allogeneic peripheral blood stem cell transplantation after the first remission, he died 9 months after the initial diagnosis due to relapse of the disease and graft-versus-host disease. The other patient was a 72 yr-old male with acute myeloid leukemia without maturation. His karyotype was 45,XY,-16,add(21)(q22) and the presence of t(16;21)(p11;q22) was detected by RT-PCR. He was transferred to another hospital with no more follow-up. We suggest that the presence of t(16;21)(p11;q22) and/or TLS/FUS-ERG fusion transcripts has to be considered in cases of AML with erythrophagocytosis.
MeSH terms
AgedChromosomes, Human, Pair 16/genetics*Chromosomes, Human, Pair 22/genetics*Graft vs Host Disease/diagnosisHumansKaryotypingLeukemia, Myeloid, Acute/diagnosisLeukemia, Myeloid, Acute/genetics*MaleOncogene Proteins, Fusion/genetics*RNA-Binding Protein FUS/genetics*Reverse Transcriptase Polymerase Chain ReactionTranslocation, Genetic*Young Adult
DOI
10.3343/kjlm.2009.29.5.390
PMID
19893346
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
박, 일중이, 현우박, 준성김, 효철김, 현주한, 재호조, 성란
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