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The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha.

DC Field Value Language
dc.contributor.authorYoo, YG-
dc.contributor.authorCho, S-
dc.contributor.authorPark, S-
dc.contributor.authorLee, MO-
dc.date.accessioned2011-06-28T04:33:28Z-
dc.date.available2011-06-28T04:33:28Z-
dc.date.issued2004-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3073-
dc.description.abstractHepatitis B virus X protein (HBx) of the hepatitis B virus is strongly implicated in angiogenesis and metastasis during hepatocarcinogenesis. Previously, we reported that HBx enhances activity of hypoxia-inducible factor-1alpha (HIF-1alpha), a potent transactivator that induces angiogenic factors. Here, we delineate the structural region of HBx that potentiates HIF-1alpha. The carboxy-terminus of HBx increased the stability of HIF-1alpha protein, probably through inhibiting interaction with von Hippel-Lindau protein. Further, the carboxy-terminus of HBx enhanced the transactivation function of HIF-1alpha by enhancing its association with CREB binding protein (CBP). Finally, we demonstrated the physical association of HBx with the basic helix-loop-helix/PER-ARNT-SIM domain, the inhibitory domain, and the carboxy-terminal transactivation domain of HIF-1alpha in vivo.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell Line-
dc.subject.MESHHumans-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit-
dc.subject.MESHMice-
dc.subject.MESHProtein Binding-
dc.subject.MESHTrans-Activators-
dc.subject.MESHTranscription Factors-
dc.subject.MESHTranscription, Genetic-
dc.titleThe carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha.-
dc.typeArticle-
dc.identifier.pmid15527772-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014579304012086-
dc.contributor.affiliatedAuthor박, 선-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.febslet.2004.10.004-
dc.citation.titleFEBS letters-
dc.citation.volume577-
dc.citation.number1-2-
dc.citation.date2004-
dc.citation.startPage121-
dc.citation.endPage126-
dc.identifier.bibliographicCitationFEBS letters, 577(1-2). : 121-126, 2004-
dc.identifier.eissn1873-3468-
dc.relation.journalidJ000145793-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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