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Lithium attenuates stress-induced impairment of long-term potentiation induction.

Authors
Lim, KY; Yang, JJ; Lee, DS; Noh, JS; Jung, MW; Chung, YK
Citation
Neuroreport, 16(14):1605-1608, 2005
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
Stress impairs the induction of long-term potentiation in the hippocampus as well as hippocampus-dependent memory. Lithium, a classical mood stabilizer, is known to have beneficial effects on stress-induced impairment of spatial memory. In the present study, we investigated lithium effects on the impairment of long-term potentiation induction after exposure to acute immobilization stress. As previously reported, immobilization stress impaired long-term potentiation induction in the CA1 region of rat hippocampal slices. Treating the slices with 0.6 or 1 mM lithium attenuated impaired long-term potentiation induction in stressed animals. Lithium was without effect on long-term potentiation induction in unstressed animals or baseline synaptic responses in unstressed or stressed animals. These results demonstrate a protective effect of lithium against stress-induced impairment of long-term potentiation induction.
MeSH terms
Analysis of VarianceAnimalsDose-Response Relationship, DrugElectric Stimulation/methodsLithium/therapeutic use*Long-Term Potentiation/drug effects*Long-Term Potentiation/physiologyLong-Term Potentiation/radiation effectsMaleNeuroprotective Agents/therapeutic use*RatsRats, Sprague-DawleyRestraint, Physical/methodsStress, Psychological/drug therapy*Stress, Psychological/physiopathology
PMID
16148754
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
임, 기영노, 재성정, 민환정, 영기
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