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Myxoid clear cell sarcoma.

Authors
Kim, YC; Vandersteen, DP; Jung, HG
Citation
The American Journal of dermatopathology, 27(1):51-55, 2005
Journal Title
The American Journal of dermatopathology
ISSN
0193-10911533-0311
Abstract
Clear cell sarcoma is a rare soft-tissue tumor presenting typically in the extremities of young adults. It has been also known as malignant melanoma of the soft parts because of the presence of melanin and cytoplasmic melanosomes. However, clear cell sarcoma is, at present, usually considered as a unique lesion because the t(12;22)(q13;q12) translocation is present only in clear cell sarcoma. Myxoid malignant melanoma is now a well-recognized morphologic variant of malignant melanoma. However, a myxoid variant of clear cell sarcoma has not been well described yet. We report a case of myxoid clear cell sarcoma occurring on the heel in a 22-year-old man. The tumor was composed of nests and fascicles of oval to fusiform cells with clear to pale eosinophilic cytoplasm, often separated by fibrous septa. The tumor cells were reactive for S-100 protein, HMB-45, and MART-1. Variably sized cysts lined by one or several layers of tumor cells were observed. Alcian blue and mucicarmine stains demonstrated prominent mucin deposition in the tumor stroma and especially in the lumen of the cysts. Fluorescence in situ hybridization for the Ewing sarcoma gene showed rearrangement in nearly all of the neoplastic cells.
MeSH terms
AdultAntigens, NeoplasmDNA, Neoplasm/analysisHumansImmunoenzyme TechniquesIn Situ Hybridization, FluorescenceMART-1 AntigenMaleMelanoma-Specific AntigensMucins/analysisMyxosarcoma/chemistryMyxosarcoma/geneticsMyxosarcoma/pathology*Neoplasm Proteins/analysisRNA-Binding Protein EWS/geneticsS100 Proteins/analysisSarcoma, Clear Cell/chemistrySarcoma, Clear Cell/geneticsSarcoma, Clear Cell/pathology*Soft Tissue Neoplasms/chemistrySoft Tissue Neoplasms/geneticsSoft Tissue Neoplasms/pathology*Tumor Markers, Biological/analysis
PMID
15677980
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
김, 유찬
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