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Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients.

Authors
Choi, JH; Suh, YJ; Lee, SK; Suh, CH; Nahm, DH; Park, HS
Citation
Journal of Korean medical science, 19(3):359-363, 2004
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Vascular endothelial growth factor (VEGF) is a multi-functional cytokine involved in inflammation, repair and angiogenesis in asthmatic airway. This study aimed to evaluate the role of VEGF in immediate bronchoconstriction induced by TDI inhalation, and in chronic TDI-asthma patients. 11 newly diagnosed TDI-asthma patients (group I), 12 chronic TDI-asthma patients with persistent asthma symptoms followed for >4 yr and 15 unexposed healthy controls were enrolled. In group I, induced sputum and serum were collected before and 7 hr after placebo- and TDI-bronchoprovocation test (BPT). In group II, induced sputum and serum were collected every 2 yr. VEGF levels were measured by ELISA. There were no significant differences in sputum and serum VEGF levels between patients and controls. Before and after placebo and TDI-BPT, no significant changes were noted in sputum and serum VEGF levels of group I. In group II patients, sputum VEGF showed variable changes at 1-yr, then decreased significantly at 2-yr (p<0.05), while serum VEGF showed variable changes at 2-yr, which decreased significantly at 4-yr (p<0.05). These results suggest that VEGF may play a minor role in immediate bronchoconstriction after TDI-BPT. In chronic TDI-asthma, VEGF may be involved to 2 yr after the diagnosis and the contribution may decrease after then.
MeSH terms
AdultAsthma/*chemically induced/*metabolismBronchi/pathologyEnzyme-Linked Immunosorbent AssayExerciseHumansMethacholine Chloride/pharmacologyMiddle AgedPlacebosSputum/*metabolismTime FactorsToluene 2,4-Diisocyanate/*pharmacologyVascular Endothelial Growth Factor A/*biosynthesis/metabolism
DOI
10.3346/jkms.2004.19.3.359
PMID
15201500
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
서, 창희남, 동호박, 해심
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