157 269

Cited 23 times in

The effect of sonication on simulated osteoarthritis. Part I: effects of 1 MHz ultrasound on uptake of hyaluronan into the rabbit synovium.

Park, SR; Jang, KW; Park, SH; Cho, HS; Jin, CZ; Choi, MJ; Chung, SI; Min, BH
Ultrasound in medicine & biology, 31(11):1551-1558, 2005
Journal Title
Ultrasound in medicine & biology
High molecular weight (MW) hyaluronan (HA) preparation is considered to be more biologically active than HAs of lower MWs. However, many of the HA preparations currently used to treat osteoarthritis (OA) have lower MWs by the enhanced penetration of HA molecules into the synovial lining cells. In this study, we determined the effectiveness of sonophoresis on the delivery of high MW HA into synovial membrane using an animal model of OA. A total of 1000 kDa (HA1000) and 3000 kDa (HA3000) HA were labeled with fluorescein and injected into the knees of rabbits. Low-intensity continuous ultrasound at 1 MHz, 400 mW/cm2 was applied to the knees for 10 min treatment bid. Synovial fluid analysis revealed increased absorption and fluorescence microscopy showed deeper penetration of both HA1000 and HA3000, more so with the latter. Histologic examination indicated that ultrasound treatment resulted in no apparent damage to the synovial membrane. These results suggest that simultaneous sonication with HA injection might compensate for the short half-life of HA. Consequently, this dual treatment would render HA a far more effective tool in the management of OA.
MeSH terms
AnimalsFemaleHalf-LifeHindlimbHyaluronic Acid/administration & dosage*Hyaluronic Acid/chemistryHyaluronic Acid/metabolismModels, AnimalMolecular WeightOsteoarthritis, Knee/metabolismOsteoarthritis, Knee/pathologyOsteoarthritis, Knee/therapy*RabbitsSonication*Synovial Fluid/chemistrySynovial Fluid/metabolismSynovial Membrane/metabolism*Synovial Membrane/pathology
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
AJOU Authors
민, 병현
Full Text Link
Files in This Item:
Full-Text Not Available.txtDownload
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.