Creation of four experimental aneurysms with different hemodynamics in one dog.

Abstract

We developed an experimental canine model in which four types of aneurysm--bifurcation, side-wall, small branch-artery, and arterial-stump--were surgically created in the same animal. These experimental aneurysms are exposed to simultaneous but different hemodynamic stresses correlating to human intracranial aneurysms in different locations. Because this model allowed for the creation of four aneurysms, each with different hemodynamic features, it seems to offer advantages from ones previously described. This model may foster investigation of new and current endovascular devices.