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Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus

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dc.contributor.authorKim, JW-
dc.contributor.authorBaek, WY-
dc.contributor.authorJung, JY-
dc.contributor.authorKim, HA-
dc.contributor.authorYang, CI-
dc.contributor.authorKim, SJ-
dc.contributor.authorSuh, CH-
dc.date.accessioned2024-02-13T23:26:59Z-
dc.date.available2024-02-13T23:26:59Z-
dc.date.issued2024-
dc.identifier.issn0014-2972-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32176-
dc.description.abstractBackground: Seasonal variation and sunlight exposure can impact serum vitamin D levels, potentially influencing lupus symptoms. We investigated seasonal vitamin D levels and their correlation with clinical manifestations and disease activity in systemic lupus erythematosus (SLE). Methods: Serum 25(OH) vitamin D3 (25(OH)D3) levels were categorised as deficient (25(OH)D3 < 10 ng/mL), insufficient (10–30 ng/mL) and sufficiency (>30 ng/mL) in participants analysed in winter (n = 407) and summer (n = 377). Logistic regression analysis was performed to assess the impact of vitamin D levels on achieving a lupus low disease activity state (LLDAS), stratified by season. Results: The mean serum 25(OH)D3 levels differed significantly between the winter and summer measurement groups (22.4 vs. 24.2 ng/mL; p =.018). The prevalences of vitamin D deficiency, insufficiency and sufficiency in the winter group were 12.8%, 66.6% and 20.6%, respectively, compared with 4.5%, 67.9% and 27.6% in the summer group. Achieving LLDAS was highest in the vitamin D sufficiency group (winter: 56.6%, summer: 55%) and lowest in the vitamin D deficiency group (winter: 15.4%, summer: 13.6%), with significant differences (all p <.001). Multivariate analysis identified SLE disease activity index ≤4, normal anti-double-stranded DNA and vitamin D sufficiency as significant factors for achieving LLDAS in both seasons. Conclusions: Sufficient vitamin D levels are important for achieving LLDAS in patients with SLE during winter and summer. Therefore, physicians should pay attention to the adequacy of vitamin D levels and consider recommending vitamin D supplementation for patients with vitamin D insufficiency.-
dc.language.isoen-
dc.subject.MESHHumans-
dc.subject.MESHLupus Erythematosus, Systemic-
dc.subject.MESHSeasons-
dc.subject.MESHVitamin D-
dc.subject.MESHVitamin D Deficiency-
dc.subject.MESHVitamins-
dc.titleSeasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus-
dc.typeArticle-
dc.identifier.pmid37725441-
dc.subject.keyworddisease activity-
dc.subject.keywordsummer-
dc.subject.keywordsystemic lupus erythematosus-
dc.subject.keywordvitamin D-
dc.subject.keywordwinter-
dc.contributor.affiliatedAuthorKim, JW-
dc.contributor.affiliatedAuthorBaek, WY-
dc.contributor.affiliatedAuthorJung, JY-
dc.contributor.affiliatedAuthorKim, HA-
dc.contributor.affiliatedAuthorSuh, CH-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/eci.14092-
dc.citation.titleEuropean journal of clinical investigation-
dc.citation.volume54-
dc.citation.number1-
dc.citation.date2024-
dc.citation.startPagee14092-
dc.citation.endPagee14092-
dc.identifier.bibliographicCitationEuropean journal of clinical investigation, 54(1). : e14092-e14092, 2024-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1365-2362-
dc.relation.journalidJ000142972-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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