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Improved diagnostic performance of susceptibility-weighted imaging with compressed sensing-sensitivity encoding and neuromelanin-sensitive MRI for Parkinson's disease and atypical Parkinsonism

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dc.contributor.authorLee, DH-
dc.contributor.authorHeo, H-
dc.contributor.authorSuh, CH-
dc.contributor.authorShim, WH-
dc.contributor.authorKim, E-
dc.contributor.authorJo, S-
dc.contributor.authorChung, SJ-
dc.contributor.authorLee, CS-
dc.contributor.authorKim, HS-
dc.contributor.authorKim, SJ-
dc.date.accessioned2024-02-13T23:27:02Z-
dc.date.available2024-02-13T23:27:02Z-
dc.date.issued2024-
dc.identifier.issn0009-9260-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32182-
dc.description.abstractAIM: To verify the diagnostic performance of the loss of nigrosome-1 on susceptibility-weighted imaging (SWI) with compressed sensing-sensitivity encoding (CS-SENSE) and neuromelanin on neuromelanin-sensitive (NM) magnetic resonance imaging (MRI) for the diagnosis of Parkinson's disease (PD) and atypical Parkinsonism. MATERIALS AND METHODS: A total of 195 patients who underwent MRI between October 2019 and February 2020, including SWI, with or without CS-SENSE, and NM-MRI, were reviewed retrospectively. Two neuroradiologists assessed the loss of nigrosome-1 on SWI and neuromelanin on the NM-MRI. The result of N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl) nortropane positron-emission tomography (PET) was set as the reference standard. RESULTS: When CS-SENSE was applied for nigrosome-1 imaging on SWI, the non-diagnostic scan rate was lowered significantly from 19.3% (17/88) to 5.6% (6/107; p=0.004). Diagnosis of PD and atypical Parkinsonism based on the loss of nigrosome-1 on SWI and based on NM-MRI showed good diagnostic value (area under the curve [AUC] 0.821, 95% confidence interval [CI] = 0.755–0.875: AUC 0.832, 95% CI = 0.771–0.882, respectively) with a substantial inter-reader agreement (κ = 0.791 and 0.681, respectively). Combined SWI and neuromelanin had a similar discriminatory ability (AUC 0.830, 95% CI = 0.770–0.880). Similarly, the diagnosis of PD was excellent. CONCLUSIONS: CS-SENSE may add value to the diagnostic capability of nigrosome-1 on SWI to reduce the nondiagnostic scan rates. Furthermore, loss of nigrosome-1 on SWI or volume loss of neuromelanin on NM-MRI may be helpful for diagnosing PD.-
dc.language.isoen-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHParkinson Disease-
dc.subject.MESHParkinsonian Disorders-
dc.subject.MESHRetrospective Studies-
dc.titleImproved diagnostic performance of susceptibility-weighted imaging with compressed sensing-sensitivity encoding and neuromelanin-sensitive MRI for Parkinson's disease and atypical Parkinsonism-
dc.typeArticle-
dc.identifier.pmid37863747-
dc.contributor.affiliatedAuthorLee, DH-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.crad.2023.09.019-
dc.citation.titleClinical radiology-
dc.citation.volume79-
dc.citation.number1-
dc.citation.date2024-
dc.citation.startPagee102-
dc.citation.endPagee111-
dc.identifier.bibliographicCitationClinical radiology, 79(1). : e102-e111, 2024-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1365-229X-
dc.relation.journalidJ000099260-
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Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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