Cited 0 times in Scipus Cited Count

The Role of Dual-Phase 18F-FP-CIT PET to Early Diagnosis of Corticobasal Syndrome

DC Field Value Language
dc.contributor.authorKim, MS-
dc.contributor.authorPark, DG-
dc.contributor.authorShin, IJ-
dc.contributor.authorAn, YS-
dc.contributor.authorYoon, JH-
dc.date.accessioned2024-02-13T23:27:05Z-
dc.date.available2024-02-13T23:27:05Z-
dc.date.issued2024-
dc.identifier.issn0363-9762-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32193-
dc.description.abstractBackground: Corticobasal syndrome (CBS) is a neurodegeneration characterized by asymmetric parkinsonism, dystonia, myoclonus, and apraxia. In the early stage, CBS presents with asymmetric parkinsonism and cortical symptoms (apraxia and alien hand), and neuroimaging finding is often vague, making early clinical differentiation from idiopathic Parkinson disease (IPD) challenging. This study was performed to delineate the specific patterns of cortical hypoperfusion, dopamine transporter (DAT) uptake using dual-phase FP-CIT PET in discriminating between CBS and IPD at early stage. Patients and Methods: The study enrolled clinically diagnosed CBS (n = 11) and IPD (n = 22) patients (age and sex matched). All participants underwent dual-phase 18F-FP-CIT PET, and regional SUV ratio (SUVR) was obtained by semiquantitative analysis. The early perfusion imaging and DAT imaging were compared between groups. Results: The regional SUVRs (early phase) of the frontal lobe, thalamus, cingulate, and caudate were significantly lower in patients with CBS, whereas the SUVR of occipital lobe was lower in the IPD group. The CBS group exhibited more prominent asymmetry than the IPD group, particularly in the perirolandic area, superior frontal gyrus, and anterior parietal lobe in early phase PET. Striatal DAT uptake (delayed phase) revealed that the caudate showed lower SUVR and prominent asymmetry in the CBS group, and the caudate-to-putamen ratio (CP ratio) was significantly lower in CBS patients (P < 0.001). Among the parameters (early and delayed), the CP ratio in DAT exhibited the most powerful discriminative power from receiver operating characteristic curve comparison (area under curve = 0.983). Conclusions: This study demonstrated that the dual-phase FP-CIT PET is useful in differentiating CBS and IPD in the early stage of the disease, and a lower CP ratio of DAT imaging is highly informative for distinguishing between corticobasal degeneration and IPD.-
dc.language.isoen-
dc.subject.MESHApraxias-
dc.subject.MESHCorticobasal Degeneration-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins-
dc.subject.MESHEarly Diagnosis-
dc.subject.MESHHumans-
dc.subject.MESHParkinson Disease-
dc.subject.MESHParkinsonian Disorders-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHTropanes-
dc.titleThe Role of Dual-Phase 18F-FP-CIT PET to Early Diagnosis of Corticobasal Syndrome-
dc.typeArticle-
dc.identifier.pmid38015725-
dc.subject.keywordcorticobasal syndrome-
dc.subject.keyworddementia-
dc.subject.keyworddopamine imaging-
dc.subject.keywordParkinson disease-
dc.subject.keywordPET-
dc.contributor.affiliatedAuthorPark, DG-
dc.contributor.affiliatedAuthorShin, IJ-
dc.contributor.affiliatedAuthorAn, YS-
dc.contributor.affiliatedAuthorYoon, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/RLU.0000000000004979-
dc.citation.titleClinical nuclear medicine-
dc.citation.volume49-
dc.citation.number2-
dc.citation.date2024-
dc.citation.startPage124-
dc.citation.endPage130-
dc.identifier.bibliographicCitationClinical nuclear medicine, 49(2). : 124-130, 2024-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1536-0229-
dc.relation.journalidJ003639762-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse