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Effects of the BH3-only protein human Noxa on mitochondrial dynamics.
DC Field | Value | Language |
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dc.contributor.author | Woo, HN | - |
dc.contributor.author | Seo, YW | - |
dc.contributor.author | Moon, AR | - |
dc.contributor.author | Jeong, SY | - |
dc.contributor.author | Choi, EK | - |
dc.contributor.author | Kim, TH | - |
dc.date.accessioned | 2010-11-26T05:15:04Z | - |
dc.date.available | 2010-11-26T05:15:04Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/321 | - |
dc.description.abstract | Mitochondria form reticular networks comprised of filamentous tubules and continuously move and change shape. Bcl-2 family proteins actively participate in the regulation of mitochondria fragmentation. Here, we show that human Noxa, which belongs to the BH3-only pro-apoptotic Bcl-2 family, causes mitochondrial fragmentation. We found that while the Bcl-2 homology 3 (BH3) domain of Noxa is not associated with mitochondrial fragmentation, the mitochondrial targeting domain (MTD) of Noxa is the region responsible for inducing fragmentation. Two leucine residues in MTD play a key role in the process. Furthermore, the lack of Noxa causes a significant reduction of Velcade-induced mitochondrial fragmentation. Together, these results provide novel insight into the role of Noxa in mitochondrial dynamics and cell death. | - |
dc.format | text/plain | - |
dc.language.iso | en | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Boronic Acids | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Hela Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leucine | - |
dc.subject.MESH | Mitochondria | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Protease Inhibitors | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2 | - |
dc.subject.MESH | Pyrazines | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | bcl-2-Associated X Protein | - |
dc.title | Effects of the BH3-only protein human Noxa on mitochondrial dynamics. | - |
dc.type | Article | - |
dc.identifier.pmid | 19540835 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S0014-5793(09)00475-X | - |
dc.contributor.affiliatedAuthor | 정, 선용 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.febslet.2009.06.029 | - |
dc.citation.title | FEBS letters | - |
dc.citation.volume | 583 | - |
dc.citation.number | 14 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 2349 | - |
dc.citation.endPage | 2354 | - |
dc.identifier.bibliographicCitation | FEBS letters, 583(14). : 2349-2354, 2009 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.relation.journalid | J000145793 | - |
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