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Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model.

Lee, ST; Chu, K; Park, JE; Lee, K; Kang, L; Kim, SU; Kim, M
Neuroscience research, 52(3):243-249, 2005
Journal Title
Neuroscience research
An animal model induced by striatal quinolinic acid (QA) injection shows ongoing striatal degeneration mimicking Huntington's disease. To study the migratory ability and the neuroprotective effect of human neural stem cells (NSCs) in this model, we transplanted NSCs (5 x 10(6)) or saline intravenously at 7 days after unilateral QA injection. NSCs-group exhibited the reduced apomorphine-induced rotation and the reduced striatal atrophy compared to the control. PCR analysis for the human-specific ERV-3 gene supported an evidence of the engraftment of human NSCs in the rat brain. X-gal+ cells were found in and around the damaged striatum and migrated NSCs differentiated into neurons and glias. This result indicates that intravenously injected human NSCs can migrate into the striatal lesion, decrease the following striatal atrophy, and induce long-term functional improvement in a glutamate toxicity-induced striatal degeneration model.
MeSH terms
AnimalsApomorphine/pharmacologyBehavior, Animal/drug effectsBehavior, Animal/physiologyCell Count/methodsCells, CulturedCorpus Striatum/drug effectsCorpus Striatum/metabolismCorpus Striatum/pathologyDNA-Binding Proteins/metabolismDisease Models, AnimalDopamine and cAMP-Regulated Phosphoprotein 32Drosophila Proteins/metabolismEndogenous Retroviruses/geneticsFunctional LateralityGalactosides/diagnostic useGlial Fibrillary Acidic Protein/metabolismHumansHuntington Disease/chemically inducedHuntington Disease/therapy*Immunohistochemistry/methodsIndoles/diagnostic useInfusions, Intravenous/methods*MaleMotor Activity/drug effectsMotor Activity/physiologyNerve Tissue Proteins/metabolismNeurons/physiology*Parvalbumins/metabolismPhosphoproteins/metabolismPhosphopyruvate Hydratase/metabolismQuinolinic AcidRNA, Messenger/biosynthesisRandom AllocationRatsRats, Sprague-DawleyRecovery of Function/physiology*Reverse Transcriptase Polymerase Chain Reaction/methodsRotarod Performance Test/methodsStem Cell Transplantation/methods*Stem Cells/physiology*Time Factorsgamma-Aminobutyric Acid/metabolism
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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