7 223

Cited 482 times in

Microglia in health and disease.

Authors
Kim, SU; de Vellis, J
Citation
Journal of neuroscience research, 81(3):302-313, 2005
Journal Title
Journal of neuroscience research
ISSN
0360-40121097-4547
Abstract
Microglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. It was del Rio Hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there has been wide recognition that microglia are immune effectors in the CNS that respond to pathological conditions and participate in initiation and progression of neurological disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and acquired immune deficiency syndrome dementia complex by releasing potentially cytotoxic molecules such as proinflammatory cytokines, reactive oxygen intermediates, proteinases and complement proteins. There is also evidence to suggest that microglia are capable of secreting neurotrophic or neuron survival factors upon activation via inflammation or injury. It is thus timely to review current status of knowledge on biology and immunology of microglia, and consider new directions of investigation on microglia in health and disease.
MeSH terms
AnimalsAntigens, Surface/metabolismCell ProliferationCentral Nervous System/cytology*Central Nervous System Diseases/pathology*Central Nervous System Diseases/physiopathologyCentral Nervous System Diseases/therapyChemokines/metabolismCytokines/metabolismGene Expression Regulation/physiologyGene Therapy/methodsHumansMicroglia/classificationMicroglia/physiology*Nerve Growth Factors/metabolismPhagocytes/physiology
DOI
10.1002/jnr.20562
PMID
15954124
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse