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Immortalized human microglial cell line: phenotypic expression.

Authors
Nagai, A; Mishima, S; Ishida, Y; Ishikura, H; Harada, T; Kobayashi, S; Kim, SU
Citation
Journal of neuroscience research, 81(3):342-348, 2005
Journal Title
Journal of neuroscience research
ISSN
0360-40121097-4547
Abstract
Microglia are a major neuroglial component of the CNS, playing an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. To understand the role of microglia in the CNS in health and diseases, we have recently established an immortalized clonal cell line of human microglia, HMO6, from human embryonic telencephalon tissue by using a retroviral vector encoding v-myc. This immortalized microglia HMO6 cell line exhibits cell-type-specific antigens for microglia, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin, and actively phagocytoses latex beads.
MeSH terms
AnimalsAntigen-Presenting Cells/metabolismCell LineCell TransplantationChemokines/metabolismCytokines/metabolismGene Expression Regulation/physiology*HumansMiceMicroglia/cytology*Microglia/physiologyPhenotype*
DOI
10.1002/jnr.20478
PMID
15957187
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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