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Suboptimal peak inspiratory flow rate in dry-powder inhaler users for chronic obstructive pulmonary disease in Korea

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dc.contributor.authorMoon, JY-
dc.contributor.authorKim, SH-
dc.contributor.authorKim, Y-
dc.contributor.authorLee, H-
dc.contributor.authorRhee, CK-
dc.contributor.authorRa, SW-
dc.contributor.authorLee, CY-
dc.contributor.authorPark, JH-
dc.contributor.authorPark, YB-
dc.contributor.authorYoo, KH-
dc.date.accessioned2024-06-19T07:07:06Z-
dc.date.available2024-06-19T07:07:06Z-
dc.date.issued2024-
dc.identifier.issn1094-5539-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32547-
dc.description.abstractBackground: A suboptimal peak inspiratory flow rate (PIFR) in dry-powder inhaler (DPI) users can lead to insufficient therapeutic effects in the treatment of chronic obstructive pulmonary disease (COPD). However, few data on the prevalence of and factors associated with suboptimal PIFR in Korean patients with COPD are available. Methods: We conducted a cross-sectional study of patients with COPD who had been using DPIs for more than three months. PIFR was measured using an In-Check DIAL G16 device. Suboptimal PIFR was defined as below the resistance-matched threshold. Multivariable logistic regression analysis was used to determine factors associated with suboptimal PIFR. Results: Of 444 DPI users with COPD, the rate of suboptimal PIFR was 22.0 % (98/444). In a multivariable analysis, significant factors associated with suboptimal PIFR were age (adjusted odds ratio [aOR] = 1.06 by 1-year increase; 95 % confidence interval [CI] = 1.02–1.09), male sex (aOR = 0.28; 95 % CI = 0.11–0.73), body mass index (BMI) (aOR = 0.91 by 1 kg/m2 increase; 95 % CI = 0.85–0.99), post-bronchodilator forced vital capacity (FVC) %pred (aOR = 0.97 by 1%pred increase; 95 % CI = 0.95–0.99), and In-Check DIAL R2-type inhaler [medium-low resistance] use (aOR = 3.70 compared with R1-type inhalers [low resistance]; 95 % CI = 2.03–7.03). Conclusions: In Korea, more than one-fifth of DPI users with COPD had a suboptimal PIFR. The factors associated with suboptimal PIFR were age, female gender, low BMI, low FVC, and R2-type inhaler use. Therefore, clinicians should carefully evaluate the possibility of suboptimal PIFR when prescribing DPIs.-
dc.language.isoen-
dc.subject.MESHAdministration, Inhalation-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHBody Mass Index-
dc.subject.MESHBronchodilator Agents-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDry Powder Inhalers-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulmonary Disease, Chronic Obstructive-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSex Factors-
dc.titleSuboptimal peak inspiratory flow rate in dry-powder inhaler users for chronic obstructive pulmonary disease in Korea-
dc.typeArticle-
dc.identifier.pmid38604404-
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1094-5539(24)00014-2-
dc.subject.keywordAdministration-
dc.subject.keywordChronic pulmonary-
dc.subject.keywordInhalation-
dc.subject.keywordInhalation devices-
dc.subject.keywordInspiratory capacity-
dc.subject.keywordObstructive disease-
dc.subject.keywordRespiratory function tests-
dc.contributor.affiliatedAuthorPark, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.pupt.2024.102298-
dc.citation.titlePulmonary pharmacology & therapeutics-
dc.citation.volume85-
dc.citation.date2024-
dc.citation.startPage102298-
dc.citation.endPage102298-
dc.identifier.bibliographicCitationPulmonary pharmacology & therapeutics, 85. : 102298-102298, 2024-
dc.identifier.eissn1522-9629-
dc.relation.journalidJ010945539-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
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