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HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity

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dc.contributor.authorPark, SY-
dc.contributor.authorPark, SY-
dc.contributor.authorSeo, S-
dc.contributor.authorKwon, HS-
dc.contributor.authorKim, SH-
dc.contributor.authorKim, SH-
dc.contributor.authorPark, HK-
dc.contributor.authorChang, YS-
dc.contributor.authorKim, CW-
dc.contributor.authorLee, BJ-
dc.contributor.authorPark, HS-
dc.contributor.authorCho, YS-
dc.contributor.authorOh, HB-
dc.contributor.authorOstrov, DA-
dc.contributor.authorWon, S-
dc.contributor.authorKim, TB-
dc.date.accessioned2024-06-19T07:07:08Z-
dc.date.available2024-06-19T07:07:08Z-
dc.date.issued2024-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32556-
dc.description.abstractBackground: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to predict this hypersensitivity reaction. We aimed to evaluate the possible involvement of genes in cefaclor induced type I hypersensitivity. Methods: Whole exome sequencing (WES) and HLA genotyping were performed in 43 patients with cefaclor induced type I hypersensitivity. In addition, homology modeling was performed to identify the binding forms of cefaclor to HLA site. Results: Anaphylaxis was the most common phenotype of cefaclor hypersensitivity (90.69%). WES results show that rs62242177 and rs62242178 located in LIMD1 region were genome-wide significant at the 5 × 10−8 significance level. Cefaclor induced type I hypersensitivity was significantly associated with HLA-DRB1∗04:03 (OR 4.61 [95% CI 1.51–14.09], P < 0.002) and HLA-DRB1∗14:54 (OR 3.86 [95% CI 1.09–13.67], P < 0.002). Conclusion: LIMD1, HLA-DRB1∗04:03 and HLA-DRB1∗14:54 may affect susceptibility to cefaclor induced type I hypersensitivity. Further confirmative studies with a larger patient population should be performed to ascertain the role of HLA-DRB1 and LIMD1 in the development of cefaclor induced hypersensitivity.-
dc.language.isoen-
dc.titleHLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity-
dc.typeArticle-
dc.identifier.pmid38638799-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021981-
dc.subject.keywordCefaclor-
dc.subject.keywordCephalosporin-
dc.subject.keywordDrug hypersensitivity-
dc.subject.keywordImmediate hypersensitivity-
dc.subject.keywordWhole exome sequencing-
dc.contributor.affiliatedAuthorPark, HS-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.waojou.2024.100901-
dc.citation.titleThe World Allergy Organization journal-
dc.citation.volume17-
dc.citation.number5-
dc.citation.date2024-
dc.citation.startPage100901-
dc.citation.endPage100901-
dc.identifier.bibliographicCitationThe World Allergy Organization journal, 17(5). : 100901-100901, 2024-
dc.identifier.eissn1939-4551-
dc.relation.journalidJ019394551-
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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