Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.
Schmidt, NO; Przylecki, W; Yang, W; Ziu, M; Teng, Y; Kim, SU; Black, PM; Aboody, KS; Carroll, RS
Neoplasia (New York, N.Y.), 7(6):623-629, 2005
Neoplasia (New York, N.Y.)
The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,707,671
Total Download :1,105,086
Today View :259
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.