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Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

Authors
Schmidt, NO; Przylecki, W; Yang, W; Ziu, M; Teng, Y; Kim, SU; Black, PM; Aboody, KS; Carroll, RS
Citation
Neoplasia (New York, N.Y.), 7(6):623-629, 2005
Journal Title
Neoplasia (New York, N.Y.)
ISSN
1522-80021476-5586
Abstract
The transplantation of neural stem cells (NSCs) offers a new potential therapeutic approach as a cell-based delivery system for gene therapy in brain tumors. This is based on the unique capacity of NSCs to migrate throughout the brain and to target invading tumor cells. However, the signals controlling the targeted migration of transplanted NSCs are poorly defined. We analyzed the in vitro and in vivo effects of angiogenic growth factors and protein extracts from surgical specimens of brain tumor patients on NSC migration. Here, we demonstrate that vascular endothelial growth factor (VEGF) is able to induce a long-range attraction of transplanted human NSCs from distant sites in the adult brain. Our results indicate that tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for NSC tropism toward brain tumors.
MeSH terms
AnimalsBrain Neoplasms/pathology*Cell Line, TumorCell MovementCell TransplantationCells, CulturedCulture Media, Conditioned/pharmacologyDose-Response Relationship, DrugEndothelium, Vascular/cytologyEnzyme-Linked Immunosorbent AssayHumansMicroscopy, FluorescenceNeovascularization, PathologicNeurons/cytology*Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSignal TransductionStem Cells/cytology*SwineTropismUmbilical Veins/cytologyUp-RegulationVascular Endothelial Growth Factor A/metabolism*Vascular Endothelial Growth Factor Receptor-1/metabolismVascular Endothelial Growth Factor Receptor-2/metabolism
PMID
16036113
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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