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Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets.

Authors
Lee, JS; Oh, TY; Kim, YK; Baik, JH; So, S; Hahm, KB; Surh, YJ
Citation
Mutation research, 579(1-2):214-224, 2005
Journal Title
Mutation research
ISSN
0027-51071873-135X
Abstract
There are multiple lines of compelling evidence from epidemiologic and laboratory studies supporting that frequent consumption of green tea is inversely associated with the risk of chronic human diseases including cancer. The chemopreventive and chemoprotective effects of green tea have been largely attributed to antioxidative and anti-inflammatory activities of its polyphenolic constituents, such as epigallocatechin gallate. The present study was designed to evaluate the efficacy of green tea polyphenols in protecting against alcohol-induced gastric damage and to elucidate the underlying mechanisms. Intragastric administration of ethanol to male Sprague-Dawley rats caused significant gastric mucosal damage, which was accompanied by elevated expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as transient activation of redox-sensitive transcription factors, such as NF-kappaB and AP-1, and mitogen-activated protein kinases (MAPKs). Oral administration of the green tea polyphenolic extract (GTE) significantly ameliorated mucosal damages induced by ethanol and also attenuated the ethanol-induced expression of COX-2 and iNOS. Inactivation of MAPKs, especially p38 and ERKl/2, by GTE might be responsible for inhibition of ethanol-induced expression of COX-2 and iNOS.
MeSH terms
AnimalsCyclooxygenase 1/drug effectsCyclooxygenase 1/metabolismCyclooxygenase 2/drug effectsCyclooxygenase 2/metabolismEthanol/adverse effects*Flavonoids/pharmacology*Gastric Mucosa/drug effects*Gastric Mucosa/metabolismGastric Mucosa/pathologyGastritis/chemically inducedGastritis/pathologyGastritis/prevention & controlHSP70 Heat-Shock Proteins/drug effectsHSP70 Heat-Shock Proteins/metabolismMaleMembrane Proteins/drug effectsMembrane Proteins/metabolismMitogen-Activated Protein Kinases/drug effects*NF-kappa B/drug effectsNF-kappa B/metabolismNitric Oxide Synthase Type II/drug effectsNitric Oxide Synthase Type II/metabolismPhenols/pharmacology*Plant Extracts/pharmacology*RatsRats, Sprague-DawleyStress, PhysiologicalTeaTranscription Factor AP-1/drug effectsTranscription Factor AP-1/metabolismTranscription Factors/drug effects*
DOI
10.1016/j.mrfmmm.2005.03.027
PMID
16095631
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
함, 기백
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