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Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia.

Authors
Baik, E; Chung, JM; Chung, K
Citation
The journal of pain : official journal of the American Pain Society, 4(4):212-221, 2003
Journal Title
The journal of pain : official journal of the American Pain Society
ISSN
1526-59001528-8447
Abstract
Inflammation of a peripheral nerve (neuritis) causes mechanical and thermal hyperalgesia in the region in which the inflamed nerve innervates. We investigated whether peripherally applied norepinephrine (NE) would exacerbate mechanical hyperalgesia in rats with neuritis. After inflammation of the left L5 spinal nerve with complete Freund's adjuvant, the foot withdrawal thresholds to mechanical stimuli applied to the affected hind paw (mechanical thresholds) were decreased significantly, indicating the development of mechanical hyperalgesia. An intradermal injection of NE to the affected paw further aggravated mechanical hyperalgesia transiently (1-3 days) and then recovered to the pre-NE injection levels afterwards. This responsiveness to NE (adrenergic sensitivity) was observed not only while rats were showing inflammatory hyperalgesia but also after recovering from it. The effect of NE on mechanical hyperalgesia was mediated by both peripheral alpha(1)- and alpha(2)-adrenoceptors. Immunohistochemical study of the previously inflamed nerve showed that proinflammatory cytokine tumor necrosis factor immunoreactivity was significantly higher in the rats showing adrenergic sensitivity compared to rats without adrenergic sensitivity. The data thus suggest that peripheral NE, when released in an excessive amount from the sympathetic nervous system, might play an important role in the aggravation of pain in neuritis.
MeSH terms
Adrenergic alpha-Agonists/administration & dosageAdrenergic alpha-Agonists/pharmacology*Adrenergic alpha-Antagonists/pharmacologyAnimalsBehavior, Animal/drug effectsFreund's AdjuvantHyperalgesia/chemically inducedHyperalgesia/etiology*Hyperalgesia/physiopathology*Injections, IntradermalMaleNeuritis/chemically inducedNeuritis/complications*Neuritis/physiopathology*Norepinephrine/administration & dosageNorepinephrine/pharmacology*Pain Threshold/drug effectsPhentolamine/pharmacologyPhysical StimulationRatsRats, Inbred WFReceptors, Adrenergic, alpha-1/drug effectsReceptors, Adrenergic, alpha-2/drug effectsSkin/innervationSpinal Nerves/drug effectsSpinal Nerves/pathologyTumor Necrosis Factor-alpha/metabolism
PMID
14622706
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
백, 은주
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