Cited 0 times in Scipus Cited Count

Intermittent hypoxia induces Th17/Treg imbalance in a murine model of obstructive sleep apnea

DC Field Value Language
dc.contributor.authorPark, DY-
dc.contributor.authorKim, CH-
dc.contributor.authorPark, DY-
dc.contributor.authorKim, HJ-
dc.contributor.authorCho, HJ-
dc.date.accessioned2024-09-10T06:21:48Z-
dc.date.available2024-09-10T06:21:48Z-
dc.date.issued2024-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/32763-
dc.description.abstractObstructive sleep apnea (OSA) is characterized by cyclic normoxic and hypoxic conditions (intermittent hypoxia, IH) induced by the repeated closure of the upper-airway respiratory tract. As a pathomechanism of OSA, IH results in various comorbidities via chronic inflammation and related pathways. However, the role of other inflammatory cells, such as lymphocytes, has not been well-explored. This study aimed to examine the effects of IH on the distribution and balance of T cell subsets and other related cytokines, and mechanisms in the immune system. We modified OSA mouse model (male C57BL/6N male) using our customized chamber that controls specific sleep and oxygenic cycles. To induce hypoxia, the IH group was repeatedly exposed to 5% O2 and 21% O2 lasting for 120 s each for 7 h daily for 4 weeks. Mice were then subjected to a recovery period of 4 weeks, in which IH stimulation was ceased. T cells and related cytokines were analyzed using flow cytometry and immunohistochemistry. Compared with the control group, the IH group had significantly lower levels of CD4+CD25+Foxp3+ regulatory T cells but higher levels of Th 17, IL-4, HIF-1, and inflammatory cytokines. After the recovery period, these altered changes in the immune cells were recovered, and we found no significant difference in their levels between the control and recovery groups. This study revealed that the Th17/Treg ratio is increased by intermittent hypoxia, and this imbalance can explain immune-related diseases, including recently reported allergies, autoimmune, and even cancer diseases, arising from OSA.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCytokines-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHHypoxia-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit-
dc.subject.MESHInterleukin-4-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHSleep Apnea, Obstructive-
dc.subject.MESHT-Lymphocytes, Regulatory-
dc.subject.MESHTh17 Cells-
dc.titleIntermittent hypoxia induces Th17/Treg imbalance in a murine model of obstructive sleep apnea-
dc.typeArticle-
dc.identifier.pmid38913648-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195984-
dc.contributor.affiliatedAuthorPark, DY-
dc.contributor.affiliatedAuthorKim, HJ-
dc.type.localJournal Papers-
dc.identifier.doi10.1371/journal.pone.0305230-
dc.citation.titlePloS one-
dc.citation.volume19-
dc.citation.number6-
dc.citation.date2024-
dc.citation.startPagee0305230-
dc.citation.endPagee0305230-
dc.identifier.bibliographicCitationPloS one, 19(6). : e0305230-e0305230, 2024-
dc.identifier.eissn1932-6203-
dc.relation.journalidJ019326203-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Files in This Item:
38913648.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse