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Calcium-dependent prevention of neuronal apoptosis by lithium ion: essential role of phosphoinositide 3-kinase and phospholipase Cgamma.

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dc.contributor.authorKang, HJ-
dc.contributor.authorNoh, JS-
dc.contributor.authorBae, YS-
dc.contributor.authorGwag, BJ-
dc.date.accessioned2011-07-13T02:10:58Z-
dc.date.available2011-07-13T02:10:58Z-
dc.date.issued2003-
dc.identifier.issn0026-895X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3298-
dc.description.abstractWe examined the possibility that the neuroprotective effects of Li+ would depend upon the patterns of neuronal death, apoptosis versus necrosis, and whether Ca2+ as well as phosphoinositide 3-kinase (PI3-K) would mediate the neuroprotective effect of Li+. Cortical neurons treated with Li+ showed marked increase in [Ca2+]i within 2 min. Addition of BAPTA-acetoxymethyl ester, a selective Ca2+ chelator, abrogated the antiapoptotic effect of Li+. PI3-K was activated rapidly within 1 min after exposure to Li+, which mediated Ca2+-dependent neuroprotective effects of Li+. Activated PI3-K seemed to increase [Ca2+]i via the phospholipase Cgamma (PLCgamma) pathway. Antiapoptosis action of Li+ was prevented in the presence of U-73122, a selective phospholipase C inhibitor, and was not observed in PLCgamma1-null fibroblasts. In contrast to antiapoptosis action, administration of Li+ did not prevent neuronal cell necrosis by excitotoxicity or free radicals. Li+ selectively prevents apoptosis by increasing [Ca2+]i through activation of PI3-K and PLCgamma pathways.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis-
dc.subject.MESHCalcium-
dc.subject.MESHDrug Interactions-
dc.subject.MESHHumans-
dc.subject.MESHLithium-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHNeurons-
dc.subject.MESHPhosphatidylinositol 3-Kinases-
dc.subject.MESHPhospholipase C gamma-
dc.subject.MESHType C Phospholipases-
dc.titleCalcium-dependent prevention of neuronal apoptosis by lithium ion: essential role of phosphoinositide 3-kinase and phospholipase Cgamma.-
dc.typeArticle-
dc.identifier.pmid12869627-
dc.identifier.urlhttp://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12869627-
dc.contributor.affiliatedAuthor노, 재성-
dc.contributor.affiliatedAuthor곽, 병주-
dc.type.localJournal Papers-
dc.identifier.doi10.1124/mol.64.2.228-
dc.citation.titleMolecular pharmacology-
dc.citation.volume64-
dc.citation.number2-
dc.citation.date2003-
dc.citation.startPage228-
dc.citation.endPage234-
dc.identifier.bibliographicCitationMolecular pharmacology, 64(2). : 228-234, 2003-
dc.identifier.eissn1521-0111-
dc.relation.journalidJ00026895X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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