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Antiapoptotic and pronecrotic actions of neurotrophins.

Authors
Gwag, BJ; Kim, SH
Citation
Antioxidants & redox signaling, 5(5):621-627, 2003
Journal Title
Antioxidants & redox signaling
ISSN
1523-08641557-7716
Abstract
Neurotrophins promote the differentiation, growth, and survival of neurons in the nervous system. Specifically, neurotrophins promote neuronal survival by interfering with programmed cell death or apoptosis. In addition to roles of neurotrophins as survival factors, neurotrophins can act as risk factors of neuronal injury under various pathological conditions. Neurotrophins markedly potentiate neuronal cell necrosis induced by activation of N-methyl-D-aspartate receptors, deprivation of oxygen and glucose, and free radicals. Moreover, prolonged exposure to neurotrophins results in widespread neuronal necrosis through free radical-mediated mechanisms. Whereas cellular and molecular mechanisms underlying antiapoptosis action of neurotrophins have been well documented, extensive study will be needed to delineate mechanisms for the neurotrophin-induced neuronal necrosis through activation of Trk tyrosine kinase receptors.
MeSH terms
AnimalsApoptosis/physiology*HumansModels, BiologicalNecrosisNerve Growth Factors/physiology*Neurons/physiologyOxidative Stress/physiologyReactive Oxygen Species/metabolismReceptors, N-Methyl-D-Aspartate/physiology
DOI
10.1089/152308603770310284
PMID
14580318
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
곽, 병주
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