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Adenoviral interleukin-3 gene-radiation therapy for prostate cancer in mouse model.

Authors
Oh, YT; Chen, DW; Dougherty, GJ; McBride, WH
Citation
International journal of radiation oncology, biology, physics, 59(2):579-583, 2004
Journal Title
International journal of radiation oncology, biology, physics
ISSN
0360-30161879-355X
Abstract
PURPOSE: The radiosensitizing effect of IL-3 gene therapy was evaluated on the syngeneic mouse prostate cancer model.



METHODS AND MATERIALS: An adenoviral vector was used to deliver the mIL-3 alpha gene into syngeneic murine prostate (TRAMP-C1) cancer cells growing in a subcutaneous site and the tumor response to irradiation was assessed.



RESULTS: Ad-mIL-3 gene therapy showed no tumor growth delay without radiation. However, intratumoral Ad-mIL-3 injection with radiation therapy showed marked tumor growth delay that was significantly greater than that of radiation alone.



CONCLUSIONS: The combined intratumoral Ad-mIL-3 gene therapy and radiation therapy is a valuable option for further clinical evaluation.
MeSH terms
Adenoviridae/geneticsAnimalsApoptosisCombined Modality TherapyGene Therapy/*methodsGenetic Vectors/therapeutic useInterleukin-3/*genetics/metabolismMaleMiceMice, Inbred C57BLProstatic Neoplasms/metabolism/radiotherapy/*therapyRadiotherapy Dosage
DOI
10.1016/j.ijrobp.2004.01.030
PMID
15145179
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
AJOU Authors
오, 영택
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