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Reduction in glycopeptide resistance in vancomycin-resistant enterococci as a result of vanA cluster rearrangements.

Citation
Antimicrobial agents and chemotherapy, 48(4):1379-1381, 2004
Journal Title
Antimicrobial agents and chemotherapy
ISSN
0066-48041098-6596
Abstract
The molecular characterization of five clinical isolates of vanA-containing vancomycin-resistant enterococci with altered resistance to glycopeptides was examined. One strain represented an IS1216V insertion accompanied by partial deletion of the reading frame of vanX following a transposition event. The other four strains represented IS1216V within the vanX-vanY intergenic region associated with deletion of vanY or vanZ.
MeSH terms
Anti-Bacterial Agents/*pharmacologyBacterial Proteins/*geneticsCarbon-Oxygen Ligases/*geneticsChromosome MappingChromosomes, Bacterial/geneticsElectrophoresis, Gel, Pulsed-FieldEnterococcus faecium/*drug effects/*geneticsGenes, Bacterial/*geneticsGenotypeGlycopeptides/*pharmacologyGram-Positive Bacterial Infections/microbiologyKoreaMultigene Family/*geneticsPhenotypeReverse Transcriptase Polymerase Chain ReactionVancomycin Resistance/*genetics
PMID
15047548
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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