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Role of dentate gyrus in aligning internal spatial map to external landmark.

Authors
Lee, JW; Kim, WR; Sun, W; Jung, MW
Citation
Learning & memory (Cold Spring Harbor, N.Y.), 16(9):530-536, 2009
Journal Title
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN
1072-05021549-5485
Abstract
Humans and animals form internal representations of external space based on their own body movement (dead reckoning) as well as external landmarks. It is poorly understood, however, how different types of information are integrated to form a unified representation of external space. To examine the role of dentate gyrus (DG) in this process, we conducted physiological and behavioral experiments using Bax knockout (Bax-KO) mice in which newly generated granule cells continue to accumulate disrupting neural circuitry specifically in the DG. Unlike in wild-type (WT) littermates, spatial firing of hippocampal neurons was completely dissociated from a distinct visual cue and instead, tended to stay constant relative to the recording room in Bax-KO mice. Behaviorally, whereas spatial learning was intact in conventional spatial reference memory tasks, Bax-KO mice were impaired in finding a target location based on visual landmarks when target locations predicted by dead reckoning and visual landmarks were made incongruent. These results provide converging evidence for the role of DG in binding animal's internal spatial map with the sensory information on external landmarks in building a distinct spatial representation for each environment.
MeSH terms
Action Potentials/physiologyAnalysis of VarianceAnimalsBehavior, Animal/physiologyCuesDentate Gyrus/cytologyDentate Gyrus/physiology*Electroencephalography/methodsFourier AnalysisLearning Disorders/geneticsLearning Disorders/physiopathologyMaze Learning/physiologyMiceMice, Inbred C57BLMice, KnockoutNeurons/physiologyPhotic StimulationSpace Perception/physiology*Spatial Behavior/physiology*bcl-2-Associated X Protein/deficiency
DOI
10.1101/lm.1483709
PMID
19706836
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정민환
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