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Endophilin B1 is required for the maintenance of mitochondrial morphology.

DC Field Value Language
dc.contributor.authorKarbowski, M-
dc.contributor.authorJeong, SY-
dc.contributor.authorYoule, RJ-
dc.date.accessioned2011-07-14-
dc.date.available2011-07-14-
dc.date.issued2004-
dc.identifier.issn0021-9525-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3330-
dc.description.abstractWe report that a fatty acyl transferase, endophilin B1, is required for maintenance of mitochondrial morphology. Down-regulation of this protein or overexpression of endophilin B1 lacking the NH(2)-terminal lipid-modifying domain causes striking alterations of the mitochondrial distribution and morphology. Dissociation of the outer mitochondrial membrane compartment from that of the matrix, and formation of vesicles and tubules of outer mitochondrial membrane, was also observed in both endophilin B1 knockdown cells and after overexpression of the truncated protein, indicating that endophilin B1 is required for the regulation of the outer mitochondrial membrane dynamics. We also show that endophilin B1 translocates to the mitochondria during the synchronous remodeling of the mitochondrial network that has been described to occur during apoptosis. Double knockdown of endophilin B1 and Drp1 leads to a mitochondrial phenotype identical to that of the Drp1 single knockdown, a result consistent with Drp1 acting upstream of endophilin B1 in the maintenance of morphological dynamics of mitochondria.-
dc.language.isoen-
dc.subject.MESHAcyltransferases/genetics/metabolism/*physiology-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/genetics-
dc.subject.MESHCOS Cells-
dc.subject.MESHDown-Regulation/genetics-
dc.subject.MESHEnergy Metabolism/*genetics-
dc.subject.MESHGTP Phosphohydrolases/genetics-
dc.subject.MESHHela Cells-
dc.subject.MESHHumans-
dc.subject.MESHIntracellular Membranes/*metabolism/ultrastructure-
dc.subject.MESHMicrotubule-Associated Proteins/genetics-
dc.subject.MESHMitochondria/genetics/*metabolism/ultrastructure-
dc.subject.MESHMitochondrial Proteins-
dc.subject.MESHPhenotype-
dc.subject.MESHProtein Transport/genetics-
dc.subject.MESHRNA Interference-
dc.titleEndophilin B1 is required for the maintenance of mitochondrial morphology.-
dc.typeArticle-
dc.identifier.pmid15452144-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172012/-
dc.contributor.affiliatedAuthor정, 선용-
dc.type.localJournal Papers-
dc.identifier.doi10.1083/jcb.200407046-
dc.citation.titleThe Journal of cell biology-
dc.citation.volume166-
dc.citation.number7-
dc.citation.date2004-
dc.citation.startPage1027-
dc.citation.endPage1039-
dc.identifier.bibliographicCitationThe Journal of cell biology, 166(7):1027-1039, 2004-
dc.identifier.eissn1540-8140-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
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