mHPpred: Accurate identification of peptide hormones using multi-view feature learning

Abstract

Peptide hormones were first used in medicine in the early 20th century, with the pivotal event being the isolation and purification of insulin in 1921. These hormones are integral to a sophisticated system that emerged early in evolution to regulate growth, development, and homeostasis. They serve as targeted signaling molecules that transfer specific information between cells and organs, ensuring coordinated and precise physiological responses. While experimental methods for identifying peptide hormones present challenges such as low abundance, stability issues, and complexity, computational methods offer promising alternatives. Advances in machine learning and bioinformatics have facilitated the prediction of peptide hormones, further enhancing their therapeutic potential. In this study, we explored three different computational frameworks for peptide hormone identification and determined that the meta-approach was the most suitable. Firstly, we evaluated the discriminative power of 26 feature descriptors using a series of baseline models and identified seven feature descriptors with high predictive potential. Through a systematic approach, we then selected the top 20 performing baseline models and integrated their predicted probabilities to train a meta-model, leveraging the strengths of multiple prediction strategies. Our final light gradient boosting-based meta-model, mHPpred, significantly outperformed the existing method, HOPPred, on both benchmarking and independent datasets. Notably, mHPpred also demonstrated superior performance compared to the hybrid and integrative framework approaches employed in this study. This superiority demonstrates the effectiveness of our multi-view feature learning strategy in capturing discriminative features and providing a more accurate prediction model for peptide hormones. mHPpred is publicly accessible at: https://balalab-skku.org/mHPpred.