5 240

Cited 13 times in

Long-term synaptic plasticity in deep layer-originated associational projections to superficial layers of rat entorhinal cortex.

Authors
Yang, S; Lee, DS; Chung, CH; Cheong, MY; Lee, CJ; Jung, MW
Citation
Neuroscience, 127(4):805-812, 2004
Journal Title
Neuroscience
ISSN
0306-45221873-7544
Abstract
Superficial layers of the entorhinal cortex (EC) relay the majority of cortical input projections to the hippocampus, whereas deep layers of the EC mediate a large portion of hippocampal output projections back to other cortical areas, suggesting a functional segregation between superficial and deep layers of the EC as input and output structures of the hippocampus, respectively. However, deep layers of the EC send associational projections to superficial layers, suggesting a potential interaction between neocortical input and hippocampus-processed output in superficial layers. This possibility was investigated by examining whether deep to superficial EC projections support long-term synaptic plasticity, and whether they interact with other pathways in superficial layers in rat medial EC slice preparations. Synaptic responses of the deep-to-superficial layer projections were verified based on field potential profiles, paired-pulse facilitation, physical separation between superficial and deep layers, and pharmacological manipulation. Long-term potentiation (LTP) was reliably induced in the deep-to-superficial layer projections by burst stimulations that emulated theta or sharp wave electroencephalogram (EEG),and it was blocked by an N-methyl-d-aspartate receptor antagonist (D-2-amino-5-phosphonopentanoic acid) and a calcium channel blocker (nifedipine). Prolonged low frequency stimulation induced long-term depression. A weak stimulation of deep layers, which induced a small degree of LTP by itself, generated a much larger degree of LTP when paired with a strong stimulation of superficial layers, indicating that the deep-to-superficial layer projections cooperate with other pathways in the superficial EC to enhance synaptic weights. Our results suggest that neocortical input and hippocampal output information are integrated in superficial layers of the EC.
MeSH terms
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacologyAnimalsEntorhinal Cortex/drug effects/*physiologyLong-Term Synaptic Depression/drug effects/*physiologyMaleNeural Pathways/drug effects/physiologyNeuronal Plasticity/drug effects/physiologyRatsRats, Sprague-DawleySynapses/drug effects/*physiology
DOI
10.1016/j.neuroscience.2004.06.001
PMID
15312893
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정, 민환
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse