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Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans.

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dc.contributor.authorLee, KJ-
dc.contributor.authorVos, R-
dc.contributor.authorJanssens, J-
dc.contributor.authorTack, J-
dc.date.accessioned2011-07-14T04:27:21Z-
dc.date.available2011-07-14T04:27:21Z-
dc.date.issued2003-
dc.identifier.issn0269-2813-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3349-
dc.description.abstractBACKGROUND: The gamma-aminobutyric acid receptor type B agonist, baclofen, inhibits transient lower oesophageal sphincter relaxations by influencing a vagal pathway. Although post-prandial proximal gastric function, which is vagally mediated, is important in the occurrence of transient lower oesophageal sphincter relaxations, the effects of baclofen on post-prandial proximal gastric motility in humans remains undetermined.
AIM: To determine the effects of baclofen on post-prandial lower oesophageal sphincter function and proximal gastric motility in healthy subjects.
METHODS: In 11 healthy volunteers, a barostat bag and an oesophageal manometric catheter with a sleeve were simultaneously positioned; 40 mg of oral baclofen or placebo was then given in a randomized, double-blind manner. Subsequently, the intragastric bag volume, oesophageal and lower oesophageal sphincter pressure and oesophageal pH were recorded during the 90 min before and 120 min after a meal.
RESULTS: During the post-prandial period, unlike the fasting period, baclofen decreased the rate of transient lower oesophageal sphincter relaxations and increased the basal lower oesophageal sphincter pressure compared with placebo. However, the meal-induced decrease in the tone and phasic contractility of the fundus was not affected by baclofen.
CONCLUSION: The gamma-aminobutyric acid receptor type B agonist, baclofen, has a potent effect on post-prandial lower oesophageal sphincter motility without altering post-prandial proximal gastric motility, suggesting differential effects of baclofen on different signals of gastrointestinal vagal afferents.
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dc.formatapplication/pdf-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHBaclofen-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHEsophagogastric Junction-
dc.subject.MESHFemale-
dc.subject.MESHGABA Agonists-
dc.subject.MESHGastric Fundus-
dc.subject.MESHGastrointestinal Motility-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMuscle Contraction-
dc.subject.MESHMuscle Relaxants, Central-
dc.subject.MESHPressure-
dc.titleDifferential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans.-
dc.typeArticle-
dc.identifier.pmid12869080-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2003&volume=18&issue=2&spage=199-
dc.contributor.affiliatedAuthor이, 광재-
dc.type.localJournal Papers-
dc.identifier.doi10.1046/j.1365-2036.2003.01605.x-
dc.citation.titleAlimentary pharmacology & therapeutics-
dc.citation.volume18-
dc.citation.number2-
dc.citation.date2003-
dc.citation.startPage199-
dc.citation.endPage207-
dc.identifier.bibliographicCitationAlimentary pharmacology & therapeutics, 18(2). : 199-207, 2003-
dc.identifier.eissn1365-2036-
dc.relation.journalidJ002692813-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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