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LTD induction suppresses LTP-induced hippocampal adult neurogenesis.

Authors
Chun, SK; Sun, W; Jung, MW
Citation
Neuroreport, 20(14):1279-1283, 2009
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.
MeSH terms
Adult Stem Cells/physiology*AnimalsBromodeoxyuridineCell CountCell ProliferationDentate Gyrus/physiology*Excitatory Postsynaptic PotentialsLong-Term Potentiation/physiology*Long-Term Synaptic Depression/physiology*MaleNeurogenesis/physiology*Perforant Pathway/physiologyProliferating Cell Nuclear Antigen/metabolismRatsRats, Sprague-DawleyStem Cell Niche/physiologyTime Factors
DOI
10.1097/WNR.0b013e3283303794
PMID
19633582
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
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