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Endothelial dysfunction and alteration of nitric oxide/ cyclic GMP pathway in patients with exercise-induced hypertension.

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dc.contributor.authorChang, HJ-
dc.contributor.authorChung, JH-
dc.contributor.authorChoi, BJ-
dc.contributor.authorChoi, TY-
dc.contributor.authorChoi, SY-
dc.contributor.authorYoon, MH-
dc.contributor.authorHwang, GS-
dc.contributor.authorShin, JH-
dc.contributor.authorTahk, SJ-
dc.contributor.authorChoi, BI-
dc.date.accessioned2011-07-14T05:32:26Z-
dc.date.available2011-07-14T05:32:26Z-
dc.date.issued2003-
dc.identifier.issn0513-5796-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3358-
dc.description.abstractThe diagnostic and prognostic implication of exaggerated blood pressure response to exercise have been controversial, with opinions ranging from a benign process to a harbinger of potential cardiovascular morbidity. Endothelial dysfunction has been demonstrated in patients with atherosclerosis and as a risk factor for coronary artery disease. However, whether the cause of exercise-induced hypertension might be related to endothelial dysfunction has not been well elucidated. We evaluated endothelial function in patients who showed a systolic blood pressure > or = 210 mmHg in males and > or = 190 mmHg in females during treadmill exercise test. We measured the endothelial function of the brachial artery in 35 patients with exercise-induced hypertension, and in 35 age- and gender-matched normal control subjects, by a high resolution ultrasound technique, and the concentration of NO2-/NO3- and cyclic guanosine monophosphate (GMP). Endothelial-dependent vasodilation was impaired in patients with hypertension compared to normal controls (3.14 +/- 0.61 vs. 6.5 +/- 0.76%, p < 0.05). The extent of vasodilation was significantly correlated with age (r=-0.28, p < 0.05) and systolic blood pressure difference (r=-0.36, p < 0.05). The levels of NO2-/NO3- and cyclic GMP at maximal exercise were significantly higher than those at rest and recovery in both controls and the hypertensive group (p < 0.05). Although there was no significant difference in the increment of NO2-/NO3- during maximal exercise between the controls and hypertensive group (55 +/- 17 vs. 56 +/- 12 micro mol/L, p=NS), cyclic GMP level during maximal exercise was significantly higher in the control group than the hypertensive group (10 +/- 1.8 vs. 8.3 +/- 2.5 pmol/ml, p 0.05). Patients with exercise-induced hypertension have poor endothelium-dependent vasodilation due to an impaired nitric oxide/cyclic GMP pathway, which may play a significant role in increasing blood pressure during exercise with inadequate peripheral adjustment to changing cardiac output.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHCyclic GMP-
dc.subject.MESHEndothelium, Vascular-
dc.subject.MESHExercise-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertension-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNitric Oxide-
dc.titleEndothelial dysfunction and alteration of nitric oxide/ cyclic GMP pathway in patients with exercise-induced hypertension.-
dc.typeArticle-
dc.identifier.pmid14703610-
dc.identifier.urlhttp://www.eymj.org/DOIx.php?id=10.3349/ymj.2003.44.6.1014-
dc.contributor.affiliatedAuthor장, 혁재-
dc.contributor.affiliatedAuthor최, 병주-
dc.contributor.affiliatedAuthor최, 태영-
dc.contributor.affiliatedAuthor최, 소연-
dc.contributor.affiliatedAuthor윤, 명호-
dc.contributor.affiliatedAuthor황, 교승-
dc.contributor.affiliatedAuthor신, 준한-
dc.contributor.affiliatedAuthor탁, 승제-
dc.contributor.affiliatedAuthor최, 병일-
dc.type.localJournal Papers-
dc.identifier.doi10.3349/ymj.2003.44.6.1014-
dc.citation.titleYonsei medical journal-
dc.citation.volume44-
dc.citation.number6-
dc.citation.date2003-
dc.citation.startPage1014-
dc.citation.endPage1020-
dc.identifier.bibliographicCitationYonsei medical journal, 44(6). : 1014-1020, 2003-
dc.identifier.eissn1976-2437-
dc.relation.journalidJ005135796-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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