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Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats.

Authors
Park, S; Hahm, KB; Oh, TY; Jin, JH; Choue, R
Citation
Digestive diseases and sciences, 49(3):384-394, 2004
Journal Title
Digestive diseases and sciences
ISSN
0163-21161573-2568
Abstract
Whether wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have antiinflammatory and antitumor activities in various cell types, possesses a gastric cytoprotective effect was investigated in an ethanol-induced gastric damage model in rats. Ethanol administration alone induced evident gastric damage including gastric hemorrhages and edema, while this gastric damage was significantly attenuated by wogonin pretreatment (30 mg/kg B.W.) 1 hr before ethanol administration. As major protective mechanisms of wogonin on ethanol-induced gastric damage, we found that wogonin showed either antiinflammatory effects through dual actions on arachidonic acid metabolism, i.e., induction of prostaglandin D2 and suppression of 5S-hydroxyeicosatetraenoic acid (5S-HETE), or preventive induction of profuse apoptosis in the stomach. Conclusively, the flavonoid wogonin could be used as a preventive agent of alcohol-induced gastropathy, whose actions were proven to be strong antiinflammation and apoptosis induction.
MeSH terms
Alanine/*analogs & derivatives/therapeutic useAnimalsAnti-Ulcer Agents/therapeutic useApoptosisArachidonic Acid/metabolismCyclooxygenase 2*Cytoprotection*Drugs, Chinese HerbalEthanol/adverse effectsGastric Mucosa/*drug effects/pathologyGastritis/*chemically induced/*prevention & controlHSP70 Heat-Shock Proteins/metabolismHydroxyeicosatetraenoic Acids/metabolismIsoenzymes/metabolismMaleProstaglandin-Endoperoxide Synthases/metabolismQuinolones/therapeutic useRandom AllocationRatsRats, Sprague-Dawley
PMID
15139485
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
함, 기백
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