Cited 0 times in Scipus Cited Count

T cell reactivity to MHC class II-bound self peptides in systemic lupus erythematosus-prone MRL/lpr mice.

DC Field Value Language
dc.contributor.authorSuh, CH-
dc.contributor.authorFreed, JH-
dc.contributor.authorCohen, PL-
dc.date.accessioned2011-07-15T05:18:20Z-
dc.date.available2011-07-15T05:18:20Z-
dc.date.issued2003-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3386-
dc.description.abstractThe epitopes recognized by pathogenic T cells in systemic autoimmune disease remain poorly defined. Certain MHC class II-bound self peptides from autoimmune MRL/lpr mice are not found in eluates from class II molecules of MHC-identical C3H mice. Eleven of 16 such peptides elicited lymph node cell and spleen cell T cell proliferation in both MRL/lpr (stimulation index = 2.03-5.01) and C3H mice (stimulation index = 2.03-3.75). IL-2 and IFN-gamma production were detected, but not IL-4. In contrast to what was seen after immunization, four self peptides induced spleen cell proliferation of T cells from naive MRL/lpr, but not from C3H and C57BL/6.H2(k), mice. These peptides were derived from RNA splicing factor SRp20, histone H2A, beta(2)-microglobulin, and MHC class II I-A(k)beta. The first three peptides were isolated from I-E(k) molecules and the last peptide was bound to I-A(k). T cell responses, evident as early as 1 mo of age, depended on MHC class II binding motifs and were inhibited by anti-MHC class II Abs. Thus, although immunization can evoke peripheral self-reactive T cells in normal mice, the presence in MRL/lpr mice of spontaneous T cells reactive to certain MHC-bound self peptides suggests that these T cells actively participate in systemic autoimmunity. Peptides eluted from self MHC class II molecules may yield important clues to T cell epitopes in systemic autoimmunity.-
dc.formattext/plain-
dc.language.isoen-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Monoclonal-
dc.subject.MESHAutoantigens-
dc.subject.MESHBinding Sites, Antibody-
dc.subject.MESHBinding, Competitive-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDisease Susceptibility-
dc.subject.MESHEpitopes, B-Lymphocyte-
dc.subject.MESHEpitopes, T-Lymphocyte-
dc.subject.MESHHistocompatibility Antigens Class II-
dc.subject.MESHHistones-
dc.subject.MESHImmunization-
dc.subject.MESHLupus Erythematosus, Systemic-
dc.subject.MESHLymphocyte Activation-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C3H-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Inbred MRL lpr-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHPeptide Fragments-
dc.subject.MESHProtein Binding-
dc.subject.MESHRibosomal Proteins-
dc.subject.MESHSpleen-
dc.subject.MESHT-Lymphocyte Subsets-
dc.subject.MESHbeta 2-Microglobulin-
dc.titleT cell reactivity to MHC class II-bound self peptides in systemic lupus erythematosus-prone MRL/lpr mice.-
dc.typeArticle-
dc.identifier.pmid12574397-
dc.identifier.urlhttp://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=12574397-
dc.contributor.affiliatedAuthor서, 창희-
dc.type.localJournal Papers-
dc.identifier.doi10.4049/jimmunol.170.4.2229-
dc.citation.titleJournal of immunology (Baltimore, Md. : 1950)-
dc.citation.volume170-
dc.citation.number4-
dc.citation.date2003-
dc.citation.startPage2229-
dc.citation.endPage2235-
dc.identifier.bibliographicCitationJournal of immunology (Baltimore, Md. : 1950), 170(4). : 2229-2235, 2003-
dc.identifier.eissn1550-6606-
dc.relation.journalidJ000221767-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse