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Detection of differential proteomes of human beta-cells during islet-like differentiation using iTRAQ labeling.
DC Field | Value | Language |
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dc.contributor.author | Jin, J | - |
dc.contributor.author | Park, J | - |
dc.contributor.author | Kim, K | - |
dc.contributor.author | Kang, Y | - |
dc.contributor.author | Park, SG | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Jun, H | - |
dc.contributor.author | Kim, Y | - |
dc.date.accessioned | 2010-11-29T06:53:01Z | - |
dc.date.available | 2010-11-29T06:53:01Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/339 | - |
dc.description.abstract | A human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release. | - |
dc.language.iso | en | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Chromatography, Liquid | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin | - |
dc.subject.MESH | Insulin-Secreting Cells | - |
dc.subject.MESH | Isotope Labeling | - |
dc.subject.MESH | Proteome | - |
dc.subject.MESH | RNA, Messenger | - |
dc.subject.MESH | Tandem Mass Spectrometry | - |
dc.title | Detection of differential proteomes of human beta-cells during islet-like differentiation using iTRAQ labeling. | - |
dc.type | Article | - |
dc.identifier.pmid | 19199707 | - |
dc.contributor.affiliatedAuthor | 강, 엽 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1021/pr800765t | - |
dc.citation.title | Journal of proteome research | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 1393 | - |
dc.citation.endPage | 1403 | - |
dc.identifier.bibliographicCitation | Journal of proteome research, 8(3). : 1393-1403, 2009 | - |
dc.identifier.eissn | 1535-3907 | - |
dc.relation.journalid | J015353893 | - |
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