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Antithrombotic effect of onion in streptozotocin-induced diabetic rat.

Authors
Jung, YS; Kim, MH; Lee, SH; Baik, EJ; Park, SW; Moon, CH
Citation
Prostaglandins, leukotrienes, and essential fatty acids, 66(4):453-458, 2002
Journal Title
Prostaglandins, leukotrienes, and essential fatty acids
ISSN
0952-32781532-2823
Abstract
In the present study, we investigated whether onion has antithrombotic effect in streptozotocin (STZ)-induced diabetic rats. In diabetic rats, serum thromboxane B(2) (TXB(2)) level was elevated compared to that in normal, and this elevation in diabetes was significantly inhibited by treatment with onion (0.5 g/ml/kg/day, i.p.) for 4 weeks. In normal rats, the serum TXB(2) level remained unaltered after the treatment with onion. To investigate in vitro effect of onion, we examined its effect on TXB(2) formation, platelet aggregation and arachidonic acid (AA)-release in platelets from diabetic and normal rats. Onion showed a significant inhibitory effect on collagen- or AA-induced TXB(2) formation with greater potency in diabetic platelets than in normal. Similarly, more potent inhibitory effects of onion in diabetes were observed in collagen- or AA-induced platelet aggregation and collagen-induced AA release response. In conclusion, these results suggest that onion can produce more beneficial antithrombotic effect in diabetes.
MeSH terms
AnimalsAntithrombins/*pharmacologyArachidonic Acids/metabolismBlood Platelets/drug effects/metabolismDiabetes Mellitus, Experimental/*chemically inducedDose-Response Relationship, DrugL-Lactate Dehydrogenase/metabolismMale*OnionsPhytotherapyPlant Extracts/*pharmacologyPlatelet Aggregation/drug effectsPlatelet Aggregation Inhibitors/pharmacologyRatsRats, Sprague-DawleyStreptozocin/pharmacologyThromboxane B2/biosynthesis/blood
DOI
10.1054/plef.2002.0373
PMID
12054917
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
정, 이숙이, 수환백, 은주문, 창현
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