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NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival.

DC Field Value Language
dc.contributor.authorYun, C-
dc.contributor.authorUm, HR-
dc.contributor.authorJin, YH-
dc.contributor.authorWang, JH-
dc.contributor.authorLee, MO-
dc.contributor.authorPark, S-
dc.contributor.authorLee, JH-
dc.contributor.authorCho, H-
dc.date.accessioned2011-07-18T07:14:44Z-
dc.date.available2011-07-18T07:14:44Z-
dc.date.issued2002-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3421-
dc.description.abstractIn this paper, we examined the cellular effect of hepatitits B virus X (HBx) in ChangX-34 cells, inducible HBx-expressing cells. High expression of HBx protein in ChangX-34 cells resulted in approximately three-fold increase in DNA synthesis and did not show apoptotic changes. Expression of HBx in these cells was accompanied by the NF-kappaB-mediated transcription. Interestingly, inhibition of NF-kappaB activity either by treatment with sulfasalazine, a specific inhibitor of NF-kappaB, or by expressing IkappaBalpha super-repressor significantly increased cell death in ChangX-34 cells but had no influence on parental Chang cells. Thus, the activation of NF-kappaB in HBx-expressing cells may play a critical role in shifting the balance toward cell survival.-
dc.language.isoen-
dc.subject.MESHAnti-Bacterial Agents/pharmacology-
dc.subject.MESHAnti-Infective Agents/pharmacology-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell Division/*physiology-
dc.subject.MESHCell Survival/*physiology-
dc.subject.MESHChloramphenicol O-Acetyltransferase/metabolism-
dc.subject.MESHColony-Forming Units Assay-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHHepatitis B Antigens/metabolism/*pharmacology-
dc.subject.MESHHumans-
dc.subject.MESHI-kappa B Proteins/pharmacology-
dc.subject.MESHLiver/physiology-
dc.subject.MESHNF-kappa B/*metabolism-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHProto-Oncogene Proteins c-rel-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHSulfasalazine/pharmacology-
dc.subject.MESHTetracyclines-
dc.subject.MESHThymidine/metabolism-
dc.subject.MESHTrans-Activators/metabolism/*pharmacology-
dc.subject.MESHTranscription Factor AP-1-
dc.subject.MESHTranscription, Genetic-
dc.subject.MESHTranscriptional Activation-
dc.titleNF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival.-
dc.typeArticle-
dc.identifier.pmid12104053-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0304383502001878-
dc.contributor.affiliatedAuthor윤, 차원-
dc.contributor.affiliatedAuthor박, 선-
dc.contributor.affiliatedAuthor이, 재호-
dc.contributor.affiliatedAuthor조, 혜성-
dc.type.localJournal Papers-
dc.citation.titleCancer letters-
dc.citation.volume184-
dc.citation.number1-
dc.citation.date2002-
dc.citation.startPage97-
dc.citation.endPage104-
dc.identifier.bibliographicCitationCancer letters, 184(1):97-104, 2002-
dc.identifier.eissn1872-7980-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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