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Caffeine-induced neuronal death in neonatal rat brain and cortical cell cultures.

Authors
Kang, SH; Lee, YA; Won, SJ; Rhee, KH; Gwag, BJ
Citation
Neuroreport, 13(15):1945-1950, 2002
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
We examined the potential neurotoxicity of caffeine and. Intraperitoneal administration of caffeine (50 mg/kg, 3 times a day) produced neuronal death in various brain areas of neonatal rats 24 h later. Caffeine at doses > 300 microM was also neurotoxic in murine cortical cell cultures. Caffeine-induced neuronal death was accompanied by cell body shrinkage and attenuated by anti-apoptotic drugs including cycloheximide, high potassium, and growth factors. Two necrotic pathways, excitotoxicity and oxidative stress, did not mediate caffeine neurotoxicity. The pro-apoptotic protease caspase-3 was activated to mediate neuronal death following exposure to caffeine. The present findings suggest that caffeine may cause caspase-3-dependent neuronal cell apoptosis in neonatal rat as well as.
MeSH terms
AnimalsAnimals, NewbornApoptosis/*drug effects/physiologyCaffeine/*toxicityCaspase 3Caspases/*drug effects/metabolismCell Size/drug effects/physiologyCells, CulturedCerebral Cortex/*drug effects/enzymology/pathologyDose-Response Relationship, DrugEnzyme Inhibitors/pharmacologyFetusGrowth Substances/pharmacologyImmunohistochemistryMiceNerve Degeneration/*chemically induced/enzymology/pathologyNeuroglia/drug effectsNeurons/*drug effects/enzymology/pathologyNeurotoxins/metabolism/toxicityOxidative Stress/drug effects/physiologyPotassium/pharmacologyRatsUp-Regulation/drug effects/physiology
PMID
12395097
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
AJOU Authors
원, 석준곽, 병주
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