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Biology and significance of T-cell apoptosis in the liver.

Authors
Park, S; Murray, D; John, B; Crispe, IN
Citation
Immunology and cell biology, 80(1):74-83, 2002
Journal Title
Immunology and cell biology
ISSN
0818-96411440-1711
Abstract
The liver has emerged as an organ with distinct immunological properties. In this review, we summarize evidence that shows that the liver can remove apoptotic, or non-apoptotic but activated, CD8+ T cells from the circulation and induce apoptosis in these activated T cells by either active or passive mechanisms. Hepatitis viruses, particularly hepatitis C virus, often establish persistent infection. We review evidence that suggests that these viruses exploit intrahepatic tolerance mechanisms to protect themselves from immune attack.
MeSH terms
AnimalsApoptosis/*immunologyCD8-Positive T-Lymphocytes/cytology/*immunologyHepacivirus/immunologyHumansLiver/cytology/*immunology/virology
DOI
10.1046/j.1440-1711.2002.01065.x
PMID
11869364
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
AJOU Authors
박, 선
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