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Eosinophil inflammation of nasal polyp tissue: relationships with matrix metalloproteinases, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta1.

Authors
Lee, YM; Kim, SS; Kim, HA; Suh, YJ; Lee, SK; Nahm, DH; Park, HS
Citation
Journal of Korean medical science, 18(1):97-102, 2003
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Eosinophil and mast cell infiltrations are consistent findings in nasal polyp tissue. Previous studies have shown that matrix metalloproteinases (MMPs) may be involved in eosinophil infiltration in airway mucosa of asthmatic patients, and that transforming growth factor-beta1 (TGF-beta1) induces extracellular matrix deposition in nasal polyp tissue. The aim of this study was to evaluate the role of MMPs and tissue-inhibitor of metalloproteinase-1 (TIMP-1) in association with TGF-beta1, eosinophils and mast cell activation in nasal polyp tissue. Nasal polyp tissues from 20 patients who underwent polypectomies were collected and prepared into tissue homogenate. Eosinophil cationic protein (ECP) and tryptase levels were measured by CAP system (Pharmacia, Sweden). MMP-2, MMP-9, TIMP-1 and TGF-beta1 levels were measured by enzyme-liked immunosorbent assay. MMP-2 was the predominant form of MMPs, followed by MMP-9 and TIMP-1. There were significant correlations between ECP, and MMP-9, MMP-2, TGF-beta1 and tryptase, but not with TIMP-1. Significant correlations were noted between tryptase, and MMP-2, MMP-9, and TGF-beta1, but not with TIMP-1. Close correlations were noted between TGF-beta1, and MMP-9 and MMP-2, but not with TIMP-1. MMP-2, MMP-9, and TGF-beta1 may contribute to eosinophil and mast cell migrations into nasal polyp tissue.
MeSH terms
AdultAsthma/complicationsBlood Proteins/analysisChemotaxis, LeukocyteEosinophil Granule ProteinsEosinophilia/etiologyEosinophilia/metabolism*Eosinophilia/pathologyEosinophils/physiologyFemaleHumansMaleMast Cells/physiologyMatrix Metalloproteinase 2/analysisMatrix Metalloproteinase 2/physiology*Matrix Metalloproteinase 9/analysisMatrix Metalloproteinase 9/physiology*Middle AgedNasal Polyps/chemistry*Nasal Polyps/etiologyNasal Polyps/pathologyRhinitis/metabolismRhinitis/pathologyRibonucleases*Serine Endopeptidases/analysisTissue Inhibitor of Metalloproteinase-1/analysisTissue Inhibitor of Metalloproteinase-1/physiology*Transforming Growth Factor beta/analysisTransforming Growth Factor beta/physiology*Transforming Growth Factor beta1Tryptases
DOI
10.3346/jkms.2003.18.1.97
PMID
12589095
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
서, 유진남, 동호박, 해심
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