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Helicobacter pylori infection promotes gastric carcinogenesis in a mice model.

Authors
Han, SU; Kim, YB; Joo, HJ; Hahm, KB; Lee, WH; Cho, YK; Kim, DY; Kim, MW
Citation
Journal of gastroenterology and hepatology, 17(3):253-261, 2002
Journal Title
Journal of gastroenterology and hepatology
ISSN
0815-93191440-1746
Abstract
BACKGROUND AND AIM: Debate that Helicobacter pylori might play a causative role in gastric carcinogenesis still exists in spite of the World Health Organization's definition of H. pylori as a class I carcinogen. In order to define the exact role of H. pylori infection in gastric carcinogenesis, we established a mice model of H. pylori infection.



METHODS: One hundred and forty-four female C57BL/6 mice were divided into nine groups according to N-methyl-N-nitrosourea (MNU) treatment and H. pylori infection. All mice were killed at the 50th or 80th week after treatment, and their histopathological changes were evaluated according to group.



RESULTS: The incidence of gastric adenocarcinoma at the 50th week was 80% in mice treated with both MNU 240 microg/L and H. pylori infection, whereas the incidence was only 27% in mice treated with only MNU 240 microg/L. Although H. pylori caused marked expansion of the proliferative zone at the surface epithelium, H. pylori infection alone caused only chronic atrophic gastritis without any evidence of carcinomas until 80 weeks. The combination of MNU and H. pylori infection also resulted in a significantly higher incidence of gastric adenoma and adenocarcinoma. Significantly higher expressions of proliferating cell nuclear antigen were noted in the gastric mucosa infected with H. pylori compared to controls.



CONCLUSIONS: These results clearly demonstrated the role of H. pylori infection, rather than direct carcinogens, in promoting gastric carcinogenesis in a mice model.
MeSH terms
Adenocarcinoma/*etiology/pathologyAdenoma/etiology/pathologyAnimalsFemaleGastric Mucosa/microbiology/pathologyGastritis, Atrophic/microbiology/pathologyHelicobacter Infections/*complications*Helicobacter pyloriMethylnitrosoureaMiceMice, Inbred C57BLProliferating Cell Nuclear Antigen/metabolismStomach Neoplasms/*etiology/pathology
PMID
11982694
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
한, 상욱김, 영배주, 희재함, 기백조, 용관김, 명욱
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