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Enantiomeric composition tests of ketoprofen in equine plasma and urine as diastereomeric (S)-(-)-1-phenylethylamides by achiral GC-MS.

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dc.contributor.authorYu, J-
dc.contributor.authorLee, G-
dc.contributor.authorJeong, Y-
dc.contributor.authorAhn, YH-
dc.contributor.authorHu, MB-
dc.contributor.authorKim, SJ-
dc.contributor.authorKim, KR-
dc.contributor.authorPaik, MJ-
dc.date.accessioned2010-11-30T02:00:21Z-
dc.date.available2010-11-30T02:00:21Z-
dc.date.issued2009-
dc.identifier.issn0009-5893-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/345-
dc.description.abstractThe enantiomeric composition of ketoprofen in equine plasma and urine after administration of a commercial racemic ketoprofen product were determined as diastereomeric (S)-(-)-1-phenylethylamidation by achiral gas chromatography-mass spectrometry in selected ion monitoring mode. This method showed linearity (r ≥ 0.9986) over the range tested (5.0-5,000 ng), with acceptable precision (% RSD ≤ 9.5) and accuracy (% RE = -3.7-7.3). The ratio of (S)-ketoprofen in plasma after 6.0 h and in urine after 71.0 h increased progressively to final values of 67.3 ± 0.1 and 91.9 ± 2.2%, respectively, attributable to the inversion of (R)-ketoprofen to (S)-ketoprofen.-
dc.language.isoen-
dc.titleEnantiomeric composition tests of ketoprofen in equine plasma and urine as diastereomeric (S)-(-)-1-phenylethylamides by achiral GC-MS.-
dc.typeArticle-
dc.contributor.affiliatedAuthor이, 광-
dc.contributor.affiliatedAuthor안, 영환-
dc.contributor.affiliatedAuthor백, 만정-
dc.type.localJournal Papers-
dc.citation.titleChromatographia-
dc.citation.volume69-
dc.citation.number1-2-
dc.citation.date2009-
dc.citation.startPage59-
dc.citation.endPage63-
dc.identifier.bibliographicCitationChromatographia, 69(1-2). : 59-63, 2009-
dc.identifier.eissn1612-1112-
dc.relation.journalidJ000095893-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
Journal Papers > Research Organization > Institute for Neuroregeneration & Stem Cell Research
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